63471-68-1Relevant academic research and scientific papers
Nucleophilic Addition of Alkanenitriles to Aldehydes via N -Silyl Ketene Imines Generated in Situ
Yoshimura, Fumihiko,Saito, Hiroki,Abe, Taiki,Tanino, Keiji
, p. 1816 - 1820 (2017/09/30)
Upon treatment with triisopropylsilyl trifluoromethanesulfonate and 2,2,6,6-tetramethylpiperidine, alkanenitriles undergo direct addition to aldehydes under mild non-basic neutral conditions to provide triisopropylsilyl ethers of β-hydroxy nitriles in goo
Ring opening of 3-bromo-2-isoxazolines to β-hydroxy nitriles
Kociolek, Martin G.,Kalbarczyk, Kyle P.
, p. 4387 - 4394 (2007/10/03)
3-Bromo-2-isoxazolines were converted to the corresponding β-hydroxy nitriles by treatment with sodium iodide in the presence of either chlorotrimethylsilane or para-toluenesulfonic acid. Both methods gave β-hydroxy nitriles under relatively mild conditio
3-Hydroxy-propanamine derived neuronal reuptake inhibitors
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, (2008/06/13)
3-Hydroxy-propanamine derivatives and acid salts thereof having chiral centers at the C1 and C2 positions exhibit synaptosomal reuptake inhibition of neurotransmitters, and as such represent a new class of psychotropic agents useful as antidepressants.
Syntheses of amino nitrones. Potential intramolecular traps for radical intermediates in monoamine oxidase-catalyzed reactions
Zhong, Boyu,Lu, Xingliang,Silverman, Richard B.
, p. 2405 - 2419 (2007/10/03)
Monoamine oxidase (MAO) is a flavin-dependent enzyme that catalyzes the oxidative deamination of a variety of amine neurotransmitters and toxic amines. Although there have been several studies that support the intermediacy of an amine radical cation and a
A new method for the preparation of β-hydroxy nitriles; Transformation of 3-bromo-2-isoxazolines to β-hydroxy nitriles by treatment of alkanethiolates
Min Hyo Seo,Youn Young Lee,Yang Mo Goo
, p. 1433 - 1439 (2007/10/02)
3-Bromo-2-isoxazolines are transformed to β-hydroxy nitriles in good yields by treatment with alkanethiolates under a very mild condition.
Electroreductive Ring-Opening of α,β-Epoxy Carbonyl Compounds and Their Homologues through Recyclable Use of Diphenyl Diselenide or Diphenyl Ditelluride as a Mediator
Inokuchi, Tsutomu,Kusumoto, Masahiko,Torii, Sigeru
, p. 1548 - 1553 (2007/10/02)
A novel access to β-hydroxy carbonyl compounds from the corresponding α,β-epoxy compounds has been attained through the recyclable use of diphenyl diselenide or diphenyl ditelluride as an electroreduction mediator in a MeOH-NaClO4-(Pt) system. α,β-Epoxy ketones are converted to the corresponding aldols in the presence of malonic esters.Similarly, α,β-epoxy esters and nitriles can be reduced to the corresponding β-hydroxy compounds in the presence of acetic acid.
