63472-04-8

Basic information

• Product Name: Metbufen
• Synonyms: Metbufen;α-Methyl-γ-oxo[1,1'-biphenyl]-4-butanoic acid
• CAS NO: 63472-04-8
• Molecular Formula: C₁₇H₁₆O₃
• Molecular Weight: 268.31
• Mol File: 63472-04-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 471.6°C at 760 mmHg
• Flash Point: 253.1°C
• Appearance: /
• Density: 1.162g/cm³
• Vapor Pressure: 1.06E-09mmHg at 25°C
• Refractive Index: 1.575
• CAS DataBase Reference: Metbufen(CAS DataBase Reference)
• NIST Chemistry Reference: Metbufen(63472-04-8)
• EPA Substance Registry System: Metbufen(63472-04-8)

Safety Data

• Hazardous Substances Data: 63472-04-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C17H16O3/c1-12(17(19)20)11-16(18)15-9-7-14(8-10-15)13-5-3-2-4-6-13/h2-10,12H,11H2,1H3,(H,19,20)

Upstream product

• 92-52-4 biphenyl 
• 4100-80-5 2-methylsuccinic anhydride 
• 19340-35-3 4-(4-biphenylyl)-4-oxo-2-methyl butanoic acid 
• 7446-70-0 aluminium trichloride 
• 98-95-3 nitrobenzene 
• 88598-79-2 2-(2-Biphenyl-4-yl-2-oxo-ethyl)-2-methyl-malonic acid diethyl ester 
• 135-73-9 2-Bromo-4'-phenylacetophenone 
• 88598-78-1 acide (biphenylyl-4)-4 methyl-2 oxo-4 carboxy-2 butyrique 
• 2170-03-8 itaconic acid anhydride 

Downstream Products

• 111259-41-7 5-Biphenyl-4-yl-3-methyl-dihydro-furan-2-one 
• 29304-68-5 Phenyl-7-methyl-2-dihydro-3,4-naphthalin 
• 29304-67-4 2-methyl-7-phenyl-3,4-dihydro-2H-naphthalen-1-one 
• 111259-56-4 (biphenylyl-4)-6 methyl-4 dihydro-4,5 pyridazine (2-H) one-3 

Relevant articles and documents

Synthesis, structure and hypocholesterolemic activity of a series of substituted 4-aryl, 4-oxo butyric acids

-

Fenbufen, a new anti inflammatory analgesic: synthesis and structure activity relationships of analogs

100 analogs of fenbufen were prepared and tested using the carrageenan, polyarthritis, and UV erythema anti inflammatory tests and the 2 phenyl 1,4 benzoquinone writhing and inflamed paw pressure analgesic tests. Only 3 retained the same full spectrum of activity as fenbufen: dl 4 (4 biphenylyl) 4 hydroxybutyric acid, dl 4 (4 biphenylyl) 1,4 butanediol, and 4 biphenylacetic acid. Fenbufen had the same spectrum of activity as aspirin, phenylbutazone, and indomethacin in the 5 tests. In addition, dose response derived potencies show fenbufen more potent than aspirin and at least as potent as phenylbutazone in all 5 tests. Two related compounds were generally similar.