63489-55-4

Basic information

• Product Name: 4-Pyridinamine,2,3,6-trifluoro-(9CI)
• Synonyms: 4-Pyridinamine,2,3,6-trifluoro-(9CI);4-amino-2,3,6-trifluoropyridine;6-trifluoropyridin-4-aMine
• CAS NO: 63489-55-4
• Molecular Formula: C5H3F3N2
• Molecular Weight: 148.09
• Product Categories: HALIDE
• Mol File: 63489-55-4.mol
• Article Data: 9

Chemical Properties

• Melting Point: 94-96 °C
• Boiling Point: 251.2±35.0 °C(Predicted)
• Appearance: /
• Density: 1.517±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: -1.72±0.10(Predicted)
• CAS DataBase Reference: 4-Pyridinamine,2,3,6-trifluoro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyridinamine,2,3,6-trifluoro-(9CI)(63489-55-4)
• EPA Substance Registry System: 4-Pyridinamine,2,3,6-trifluoro-(9CI)(63489-55-4)

Safety Data

• Hazardous Substances Data: 63489-55-4(Hazardous Substances Data)

Usage

General Description

4-Pyridinamine,2,3,6-trifluoro-(9CI) is a chemical compound with the molecular formula C5H3F3N2. It is a derivative of pyridine, a six-membered heterocyclic ring consisting of five carbon atoms and one nitrogen atom. The presence of three fluorine atoms on the 2nd, 3rd, and 6th positions of the pyridine ring makes this compound a trifluoro derivative. This chemical may have potential applications in the pharmaceutical industry, agrochemicals, or material science due to its unique properties. Further research and studies are needed to explore the potential uses and properties of 4-Pyridinamine,2,3,6-trifluoro-(9CI) in various fields.

Upstream product

• 2176-62-7 2,3,4,5,6-pentachloropyridine 
• 1737-93-5 3,5-dichloro-2,4,6-trifluoropyridine 
• 1682-20-8 2,3,5,6-tetrafluoropyridin-4-amine 
• 1735-84-8 3-chloro-2,4,5,6-tetrafluoropyridine 
• 2693-57-4 4-amino-3-chloro-2,5,6-trifluoropyridine 
• 3512-13-8 2,3,4,6-tetrafluoropyridine 

Downstream Products

• 405231-13-2 4,6,7-trifluoro-3-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo[4,5-c]pyridine 
• 405231-12-1 4,6,7-trifluoro-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo[4,5-c]pyridine 
• 405230-88-8 4-amino-3-nitro-2,5,6-trifluoropyridine 
• 405230-95-7 4,6,7-trifluoroimidazo[4,5-c]pyridine 
• 6256-96-8 3,4-diamino-2,5,6-trifluoropyridine 

Relevant articles and documents

Preparation method of 4-aminopyridine compound

The invention discloses a preparation method of a 4-aminopyridine compound. The preparation method comprises the following steps: adding a 4-amino- 3-chloropyridine compound or a 4-amino-3, 5-dichloropyridine compound, potassium phosphate and a catalyst into a solvent, and reacting at 0-10 MPa and 0-100 DEG C for 4-12 hours. According to the preparation method of the 4-aminopyridine compound, therelated raw materials are easy to obtain or self-make, the cost is low, the preparation method is simple, the reaction efficiency is high, the raw material cost is low, and byproducts have economic value; meanwhile, the reaction involved in the invention has good universality and tolerance to functional groups.

Prediction of 19F NMR Chemical Shifts for Fluorinated Aromatic Compounds

Scaling factors are reported for use in predicting 19F NMR chemical shifts for fluorinated (hetero)aromatic compounds with relatively low levels of theory. Our recommended scaling factors were developed using a curated data set of 52 compounds, with 100 individual 19F shifts spanning a range of 153 ppm. With a maximum deviation of 6.5 ppm between experimental and computed shifts, or 4% of the range tested, these scaling factors allow for the assignment of chemical shifts to specific fluorines in multifluorinated aromatics. The utility of this approach is highlighted by several structural reassignments.

Novel nucleosides and related processes, pharmaceutical compositions and methods

The invention provides novel nucleosides and related processes, pharmaceutical compositions, and methods. The novel nucleosides are useful in a wide variety of antiviral, antineoplastic, and antibacterial applications. Preferred embodiments of the instant invention include novel 2 halogen-substituted, 3 halogen-substituted, and 2′,3′dihalogen-substituted analogues of 3-deazaadenosine, and novel 3 halogen-substituted analogues of 3-deazaguanosine. Compounds of the instant invention, including 4-Amino-6-fluoro-1-(β-D-ribofuranosyl)imidazo[4,5-c]pyridine and 6-Amino-7-bromo-1,5-dihydro-1-β-D-ribofuranosylimidazo[4,5-c]pyridin-4-one, have exhibited potent antiviral and anticancer activity in vitro. The compounds are also useful in the concomitant treatment of bacterial infections associated with viral infections such as AIDS.