63489-55-4

Usage

Uses

Used in Pharmaceutical Industry:
4-Pyridinamine,2,3,6-trifluoro-(9CI) is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure, including the presence of fluorine atoms, can potentially enhance the pharmacological properties of the resulting drugs, such as improving their bioavailability, selectivity, and potency.
Used in Agrochemicals:
In the agrochemical industry, 4-Pyridinamine,2,3,6-trifluoro-(9CI) may be utilized as a building block for the development of novel pesticides or herbicides. The trifluoro substitution on the pyridine ring could contribute to the compound's ability to target specific pests or weeds, thereby increasing the effectiveness and selectivity of the agrochemical products.
Used in Material Science:
4-Pyridinamine,2,3,6-trifluoro-(9CI) may also find applications in material science, particularly in the development of new materials with unique properties. The presence of fluorine atoms and the pyridine ring structure could potentially influence the compound's electronic, optical, or mechanical properties, making it suitable for use in various material applications, such as sensors, catalysts, or advanced materials for electronics and energy storage.

Upstream product

• 1735-84-8 3-chloro-2,4,5,6-tetrafluoropyridine 
• 2176-62-7 2,3,4,5,6-pentachloropyridine 
• 1737-93-5 3,5-dichloro-2,4,6-trifluoropyridine 
• 1682-20-8 2,3,5,6-tetrafluoropyridin-4-amine 
• 2693-57-4 4-amino-3-chloro-2,5,6-trifluoropyridine 
• 3512-13-8 2,3,4,6-tetrafluoropyridine 

Downstream Products

• 405231-13-2 4,6,7-trifluoro-3-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo[4,5-c]pyridine 
• 405231-12-1 4,6,7-trifluoro-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo[4,5-c]pyridine 
• 405230-88-8 4-amino-3-nitro-2,5,6-trifluoropyridine 
• 405230-95-7 4,6,7-trifluoroimidazo[4,5-c]pyridine 
• 6256-96-8 3,4-diamino-2,5,6-trifluoropyridine 

Relevant academic research and scientific papers

Preparation method of 4-aminopyridine compound

The invention discloses a preparation method of a 4-aminopyridine compound. The preparation method comprises the following steps: adding a 4-amino- 3-chloropyridine compound or a 4-amino-3, 5-dichloropyridine compound, potassium phosphate and a catalyst into a solvent, and reacting at 0-10 MPa and 0-100 DEG C for 4-12 hours. According to the preparation method of the 4-aminopyridine compound, therelated raw materials are easy to obtain or self-make, the cost is low, the preparation method is simple, the reaction efficiency is high, the raw material cost is low, and byproducts have economic value; meanwhile, the reaction involved in the invention has good universality and tolerance to functional groups.

INHIBITORS OF THE BCL6 BTB DOMAIN PROTEIN-PROTEIN INTERACTION AND USES THEREOF

The present application relates to compounds of Formula I (I) or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, and various uses in the treatment of diseases, disorders or conditions that are treatable by inhibiting interactions with BCL6 BTB, such as cancer.

Prediction of 19F NMR Chemical Shifts for Fluorinated Aromatic Compounds

Scaling factors are reported for use in predicting 19F NMR chemical shifts for fluorinated (hetero)aromatic compounds with relatively low levels of theory. Our recommended scaling factors were developed using a curated data set of 52 compounds, with 100 individual 19F shifts spanning a range of 153 ppm. With a maximum deviation of 6.5 ppm between experimental and computed shifts, or 4% of the range tested, these scaling factors allow for the assignment of chemical shifts to specific fluorines in multifluorinated aromatics. The utility of this approach is highlighted by several structural reassignments.

Selective hydrodechlorination of fluorinated arylamines

Chlorine-containing polyfluorinated anilines and meta-phenylenediamines undergo selective hydrodechlorination easily upon reduction by zinc in aqueous ammonia. A new approach is thus provided to synthetically valuable, partially fluorinated arylamines based on utilizing polyfluorochloroarenes, which are available as intermediates of perfluoroarene production from perchloroarenes. When chlorine atoms are present in positions both ortho and para to the amino group, para chlorine is initially eliminated. Based on this reaction, a one-pot synthesis of partially fluorinated 4-aminopyridines from 3,5-dichlorotrifluoro- and 3-chlorotetrafluoropyridine has been realized.

Novel nucleosides and related processes, pharmaceutical compositions and methods

The invention provides novel nucleosides and related processes, pharmaceutical compositions, and methods. The novel nucleosides are useful in a wide variety of antiviral, antineoplastic, and antibacterial applications. Preferred embodiments of the instant invention include novel 2 halogen-substituted, 3 halogen-substituted, and 2′,3′dihalogen-substituted analogues of 3-deazaadenosine, and novel 3 halogen-substituted analogues of 3-deazaguanosine. Compounds of the instant invention, including 4-Amino-6-fluoro-1-(β-D-ribofuranosyl)imidazo[4,5-c]pyridine and 6-Amino-7-bromo-1,5-dihydro-1-β-D-ribofuranosylimidazo[4,5-c]pyridin-4-one, have exhibited potent antiviral and anticancer activity in vitro. The compounds are also useful in the concomitant treatment of bacterial infections associated with viral infections such as AIDS.

HETEROCYCLIC KINASE INHIBITORS

Compounds having the formula (I) are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

A new approach to polyfluoroaromatic amines with an unsubstituted position ortho to the amino group

N-acetyl derivatives of polyfluoroaromatic amines have been found to be highly selectively defluorinated by zinc in aqueous ammonia at the position ortho to the acetamido group thus affording a new approach to potential building blocks for the synthesis o

Synthesis of halogen-substituted 3-deazaadenosine and 3-deazaguanosine analogues as potential antitumor/antiviral agents

Various 2-halogen-substituted analogues (38, 39, 43 and 44), 3-halogensubstituted analogues (51 and 52), and 2′,3′ -dihalogen- substituted analogues (57-60) of 3-deazaadenosine and 3-halogen-substituted analogues (61 and 62) of 3-deazaguanosine have been synthesized as potential anticancer and/or antiviral agents. Among these compounds, 3-deaza-3-bromoguanosine (62) showed significant cytotoxicity against L1210, P388, CCRF-CEM and B16F10 cell lines in vitro, producing IC50 values of 3, 7, 9 and 7μM, respectively. Several 3-deazaadenosine analogues (38, 51, 57 and 59) showed moderate to weak activity against hepatitis B virus.

MECHANISM FOR REACTIONS OF HALOGENATED COMPOUNDS. PART 4. ACTIVATING INFLUENCES OF RING-NITROGEN AND TRIFLUOROMETHYL IN NUCLEOPHILIC AROMATIC SUBSTITUTION

Rate constants have been measured for the reactions of ammonia with various fluorinated pyridines and diazines in aqueous dioxan at 25 deg C.From the results the activating effects of ring-nitrogen (relative to C-H) and of trifluoromethyl (relative to -H)