2693-57-4

Basic information

• Product Name: 4-AMINO-3-CHLORO-2,5,6-TRIFLUOROPYRIDINE
• Synonyms: 4-AMINO-3-CHLORO-2,5,6-TRIFLUOROPYRIDINE;TIMTEC-BB SBB000238;3-chloro-2,5,6-trifluoro-4-aMinopyridine;3-chloro-2,5,6-trifluoropyridin-4-amine
• CAS NO: 2693-57-4
• Molecular Formula: C₅H₂ClF₃N₂
• Molecular Weight: 182.53
• Product Categories: C5Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyridines
• Mol File: 2693-57-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 120-121 °C(lit.)
• Boiling Point: 243.8 °C at 760 mmHg
• Flash Point: 101.3 °C
• Appearance: /
• Density: 1.666 g/cm³
• Vapor Pressure: 0.0314mmHg at 25°C
• Refractive Index: 1.523
• Storage Temp.: 2-8°C
• PKA: -3.66±0.10(Predicted)
• CAS DataBase Reference: 4-AMINO-3-CHLORO-2,5,6-TRIFLUOROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-3-CHLORO-2,5,6-TRIFLUOROPYRIDINE(2693-57-4)
• EPA Substance Registry System: 4-AMINO-3-CHLORO-2,5,6-TRIFLUOROPYRIDINE(2693-57-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-36/37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 2693-57-4(Hazardous Substances Data)

Usage

General Description

4-Amino-3-chloro-2,5,6-trifluoropyridine is a chemical compound with the molecular formula C5H3ClF3N2. It is a heterocyclic aromatic compound with a pyridine ring substituted with an amino group, a chlorine atom, and three fluorine atoms. 4-AMINO-3-CHLORO-2,5,6-TRIFLUOROPYRIDINE is commonly used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is known for its use as an intermediate in the production of pesticides, herbicides, and fungicides due to its potent biological activity against plant pathogens. Additionally, it is also used as a building block in the development of various pharmaceutical drugs and as a reagent in organic synthesis. Overall, 4-Amino-3-chloro-2,5,6-trifluoropyridine is an important chemical compound with a wide range of industrial applications.

InChI:InChI=1/C5H2ClF3N2/c6-1-3(10)2(7)5(9)11-4(1)8/h(H2,10,11)

Upstream product

• 39066-43-8 4-azido-2,5,6-trifluoro-3-chloropyridine 
• 108-67-8 1,3,5-trimethyl-benzene 
• 1735-84-8 3-chloro-2,4,5,6-tetrafluoropyridine 
• 7664-41-7 ammonia 
• 2176-62-7 2,3,4,5,6-pentachloropyridine 
• 1737-93-5 3,5-dichloro-2,4,6-trifluoropyridine 

Downstream Products

• 63489-55-4 4-Amino-2,3,6-trifluoropyridine 
• 405231-13-2 4,6,7-trifluoro-3-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo[4,5-c]pyridine 
• 405231-12-1 4,6,7-trifluoro-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo[4,5-c]pyridine 
• 405230-88-8 4-amino-3-nitro-2,5,6-trifluoropyridine 
• 405230-95-7 4,6,7-trifluoroimidazo[4,5-c]pyridine 
• 6256-96-8 3,4-diamino-2,5,6-trifluoropyridine 
• 1235471-34-7 4,5-dihydro-3-(2,4,5-trifluorophenyl)isoxazole-5-carboxylic acid 5-chloro-2,3,6-trifluoropyridin-4-ylamide 
• 1235471-33-6 3-[4-(trifluoromethyl)phenyl]isoxazole-5-carboxylic acid 5-chloro-2,3,6-trifluoropyridin-4-ylamide 
• 1235471-38-1 3-[3-(trifluoromethyl)phenyl]isoxazole-5-carboxylic acid 5-chloro-2,3,6-trifluoropyridin-4-ylamide 

Relevant articles and documents

Preparation method of 4-aminopyridine compound

The invention discloses a preparation method of a 4-aminopyridine compound. The preparation method comprises the following steps: adding a 4-amino- 3-chloropyridine compound or a 4-amino-3, 5-dichloropyridine compound, potassium phosphate and a catalyst into a solvent, and reacting at 0-10 MPa and 0-100 DEG C for 4-12 hours. According to the preparation method of the 4-aminopyridine compound, therelated raw materials are easy to obtain or self-make, the cost is low, the preparation method is simple, the reaction efficiency is high, the raw material cost is low, and byproducts have economic value; meanwhile, the reaction involved in the invention has good universality and tolerance to functional groups.

Synthesis of halogen-substituted 3-deazaadenosine and 3-deazaguanosine analogues as potential antitumor/antiviral agents

Various 2-halogen-substituted analogues (38, 39, 43 and 44), 3-halogensubstituted analogues (51 and 52), and 2′,3′ -dihalogen- substituted analogues (57-60) of 3-deazaadenosine and 3-halogen-substituted analogues (61 and 62) of 3-deazaguanosine have been synthesized as potential anticancer and/or antiviral agents. Among these compounds, 3-deaza-3-bromoguanosine (62) showed significant cytotoxicity against L1210, P388, CCRF-CEM and B16F10 cell lines in vitro, producing IC50 values of 3, 7, 9 and 7μM, respectively. Several 3-deazaadenosine analogues (38, 51, 57 and 59) showed moderate to weak activity against hepatitis B virus.