634902-32-2

Upstream product

• 634902-31-1 4-methoxy-1-(4-methoxybenzyl)-2,5-dihydro-1H-2-azolone 
• 2393-23-9 4-methoxy-benzylamine 

Downstream Products

• 1173068-35-3 tert-butyl 4-(1-(4-methoxybenzyl)-3-(1-(4-methoxybenzyl)-5-oxopyrrolidin-3-ylamino)-5-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl)piperazine-1-carboxylate 
• 634902-46-8 (5S)-4-[(S)-2-(1-methoxy-1-ethylpropyl)pyrrolidin-1-yl]-1-(4-methoxybenzyl)-5-benzyl-2,5-dihydro-1H-2-azolone 
• 1026614-79-8 (S)-5-Benzyl-1-(4-methoxy-benzyl)-pyrrolidine-2,4-dione 
• 634902-30-0 4-[(S)-2-(1-methoxy-1-ethylpropyl)pyrrolidin-1-yl]-1-(4-methoxybenzyl)-2,5-dihydro-1H-2-azolone 

Relevant academic research and scientific papers

A Flexible Approach to (S)-5-Alkyl Tetramic Acid Derivatives: Application to the Asymmetric Synthesis of (+)-Preussin and Protected (3S,4S)-AHPPA

(Equation presented) A flexible asymmetric approach to 5-alkyl tetramic acid derivatives is described, which is based on the use of 9 as the first synthetic equivalent to chiral nonracemic tetramic acid 5-carbanionic synthon 9b. The existence of the carbanion intermediate 9b was proven by trapping with trimethylchlorosilane. Application of the present method to the synthesis of antifungal alkaloid (+)-preussin, as well as protected (3S,4S)-AHPPA 6, is also described.