1026614-79-8

Basic information

• Product Name: (S)-5-Benzyl-1-(4-methoxy-benzyl)-pyrrolidine-2,4-dione
• Synonyms: (S)-5-Benzyl-1-(4-methoxy-benzyl)-pyrrolidine-2,4-dione
• CAS NO: 1026614-79-8
• Molecular Weight: 309.365
• Mol File: 1026614-79-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-5-Benzyl-1-(4-methoxy-benzyl)-pyrrolidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-5-Benzyl-1-(4-methoxy-benzyl)-pyrrolidine-2,4-dione(1026614-79-8)
• EPA Substance Registry System: (S)-5-Benzyl-1-(4-methoxy-benzyl)-pyrrolidine-2,4-dione(1026614-79-8)

Safety Data

• Hazardous Substances Data: 1026614-79-8(Hazardous Substances Data)

Upstream product

• 1258512-74-1 (S)-methyl 2-(bromo-N-(4-methoxybenzyl)acetamido)-3-phenylpropanoate 
• 634902-30-0 4-[(S)-2-(1-methoxy-1-ethylpropyl)pyrrolidin-1-yl]-1-(4-methoxybenzyl)-2,5-dihydro-1H-2-azolone 
• 634902-32-2 1-(4-methoxybenzyl)pyrrolidine-2,4-dione 
• 2393-23-9 4-methoxy-benzylamine 
• 100-39-0 benzyl bromide 
• 634902-46-8 (5S)-4-[(S)-2-(1-methoxy-1-ethylpropyl)pyrrolidin-1-yl]-1-(4-methoxybenzyl)-5-benzyl-2,5-dihydro-1H-2-azolone 
• 634902-31-1 4-methoxy-1-(4-methoxybenzyl)-2,5-dihydro-1H-2-azolone 

Relevant articles and documents

Tetramic acids and derivatives by telluride-triggered dieckmann cyclizations

Treatment of α-bromoacyl amides of esters of N-protected α-amino acids with lithium telluride yields an amide enolate which cyclizes to unstable tetramic acids (2, 4-pyrrolidinediones) which can be converted to stable derivatives (e.g. enol esters, silyl enol ethers, enol tosylates). Reaction conditions are modified to reduce unwanted side reactions: protonation of the enolate, selfcatalyzed intermolecular aldol rections of the tetramic acids, and potential racemization at the α-carbon atom of the amino acid.