63494-84-8

Usage

Uses

Used in Pharmaceutical Industry:
(Isobutylidenebenzoyl)hydrazide is used as a key intermediate in the synthesis of drugs that possess anti-inflammatory, analgesic, and antipyretic properties. Its role in creating these medications is vital for managing pain, reducing inflammation, and lowering fever, contributing to improved patient care and treatment options.
Used in Material Science:
In the material science field, (isobutylidene)benzohydrazide is utilized as a stabilizer in the production of polyvinyl chloride (PVC). Its inclusion ensures the stability and longevity of PVC products, which are widely used in various applications such as construction, automotive, and healthcare industries.
Used in Industrial Processes:
(Isobutylidenebenzoyl)hydrazide also serves as a corrosion inhibitor in certain industrial processes. By mitigating the effects of corrosion, it helps to extend the life of equipment and infrastructure, thereby reducing maintenance costs and downtime.
Used in Neurodegenerative Disease Research:
Although still in the research phase, (isobutylidene)benzohydrazide has been studied for its potential application in the treatment of neurodegenerative diseases. Its exploration in this area signifies the ongoing pursuit of innovative therapies to combat such conditions and improve patient outcomes.

Upstream product

• 613-94-5 benzoic acid hydrazide 
• 78-84-2 isobutyraldehyde 

Downstream Products

• 95022-55-2 α-(α'-Formyl-β'-benzoyl-hydrazino)-isovaleriansaeure-tert.-butylamid 
• 94440-16-1 C₁₉H₂₇N₃O₃ 
• 94868-52-7 2-(N-Acetyl-N'-benzoyl-hydrazino)-N-cyclohexyl-3-methyl-butyramide 
• 95275-48-2 2-[N'-Benzoyl-N-(2-chloro-acetyl)-hydrazino]-N-tert-butyl-3-methyl-butyramide 
• 104217-22-3 2-phenyl-5-(propan-2-yl)-1,3,4-oxadiazole 
• 1448781-75-6 ((3R,3aS,6aS)-3-isopropyl-2,3,3a,4-tetrahydrocyclopenta[c]pyrazol-1(6aH)-yl)(phenyl)methanone 
• 1378469-97-6 C₂₀H₂₂N₂O₃ 

Relevant academic research and scientific papers

Sodium hypochlorite-mediated synthesis of 2,5-disubstituted 1,3,4-oxadiazoles from hydrazides and aldehydes

[Figure not available: see fulltext.] A simple and convenient method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles has been developed. Structurally divergent symmetrical and unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles can be obtained in moderate to high yields via NaOCl-mediated oxidative cyclization of N-acylhydrazones, generated in situ from aliphatic and aromatic hydrazides and aldehydes.

Tin Powder-Promoted One-Pot Construction of α-Methylene-γ-lactams and Spirolactams from Aldehydes or Ketones, Acylhydrazines, and 2-(Bromomethyl)acrylate

A concise and efficient method for the synthesis of α-methylene-γ-lactams is developed from multicomponent one-pot reactions of aldehydes or ketones, hydrazides, and ethyl 2-(bromomethyl)acrylate promoted by tin powder. The reaction proceeds smoothly under mild reaction conditions without using any catalyst to give the corresponding products in high yields. α-Methylene-γ-spirolactams can also be prepared from cyclic ketones.

I2-mediated oxidative C-O bond formation for the synthesis of 1,3,4-oxadiazoles from aldehydes and hydrazides

A practical and transition-metal-free oxidative cyclization of acylhydrazones into 1,3,4-oxadiazoles has been developed by employing stoichiometric molecular iodine in the presence of potassium carbonate. The conditions of this cyclization reaction also work well with crude acylhydrazone substrates obtained from the condensation of aldehydes and hydrazides. A series of symmetrical and asymmetrical 2,5-disubstituted (aryl, alkyl, and/or vinyl) 1,3,4-oxadiazoles can be conveniently generated in an efficient and scalable fashion.

Studies on the synthesis of 2-alkyl-5-aryl-1,3,4-oxadiazolines from N-acylhydrazones

Reaction of N-acylhydrazones with benzyloxyacetyl chloride in the presence of i-Pr2EtN affords new 1,3,4-oxadiazolines in excellent yields (72-95%), under mild reaction conditions and in short reaction times. The structures of the products were confirmed by single-crystal X-ray diffractometry. A plausible reaction mechanism is proposed. Georg Thieme Verlag Stuttgart · New York.

Asymmetric Br?nsted acid catalyzed cycloadditions-efficient enantioselective synthesis of pyrazolidines, pyrazolines, and 1,3-diamines from N-acyl hyrazones and alkenes

A general, metal-free, highly enantioselective Bronsted acid catalyzed [3+2] cycloaddition between hydrazones and alkenes has been developed that affords pyrazolidine derivatives (see scheme). The resulting optically active pyrazolidines can undergo many chemical transformations which allow, for example, the enantioselective synthesis of valuable pyrazolines and 1,3-diamines. Copyright

Hydrophosphonylation of benzoylhydrazones using iodine as a catalyst: A facile synthesis of α-(N′-acylhydrazino)-substituted phosphonates

A simple and efficient method for the synthesis of α-(N′- acylhydrazino)-substituted phosphonates has been developed using the hydrophosphonylation of benzoylhydrazones with triethyl phosphite in the presence of iodine as a catalyst at room temperature. The products are formed in excellent yields (89-95%) within two to three hours. Georg Thieme Verlag Stuttgart - New York.