63497-60-9

Basic information

• Product Name: IFLAB-BB F1962-0261
• Synonyms: 8-Chloro-1H-benzo[d][1,3]oxazine-2,4-dione;8-chloro-2,4-dihydro-1H-3,1-benzoxazine-2,4-dione;IFLAB-BB F1962-0261;3-Chloro-2H-3,1-benzoxazine-2,4(1H)-dione;3-Chloroisatoic anhydride;8-Chloro-2-hydroxy-4H-benzo[d][1,3]oxazin-4-one;8-chloro-2H-3,1-benzoxazine-2,4(1H)-dione
• CAS NO: 63497-60-9
• Molecular Formula: C₈H₄ClNO₃
• Molecular Weight: 197.58
• EINECS: 1533716-785-6
• Mol File: 63497-60-9.mol
• Article Data: 21

Chemical Properties

• Melting Point: 227-232 °C
• Appearance: /
• Density: 1.54 g/cm³
• Refractive Index: 1.6
• PKA: 9.70±0.20(Predicted)
• CAS DataBase Reference: IFLAB-BB F1962-0261(CAS DataBase Reference)
• NIST Chemistry Reference: IFLAB-BB F1962-0261(63497-60-9)
• EPA Substance Registry System: IFLAB-BB F1962-0261(63497-60-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 63497-60-9(Hazardous Substances Data)

Usage

General Description

IFLAB-BB F1962-0261 is a chemical compound commonly referred to as IFLAB. It is a thiol-specific fluorescent dye that is used for the labeling and detection of thiol-containing proteins and small molecules in biological samples. IFLAB-BB F1962-0261 is known for its high specificity and sensitivity for thiol groups, making it a valuable tool for the study of redox biology and the detection of oxidative stress in cells and tissues. IFLAB-BB F1962-0261 has been widely used in research and diagnostic applications to study the role of thiol oxidation in various disease states, such as cancer, cardiovascular disease, and neurodegenerative disorders. Its ability to selectively label and detect thiol groups makes it an important tool for understanding the role of thiols in biological processes and disease mechanisms.

InChI:InChI=1/C8H4ClNO3/c9-5-3-1-2-4-6(5)10-8(12)13-7(4)11/h1-3H,(H,10,12)

Upstream product

• 7477-63-6 7-chloroisatin 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 6388-47-2 2-amino-3-chlorobenzoic acid 
• 63498-13-5 N-ethoxycarbonyl-3-chloro-anthranilic acid 
• 51108-30-6 4-chloro-1H-isoindole-1,3(2H)-dione 
• 117-21-5 3-chlorophthalic anhydride 
• 126-71-6 triisobutyl phosphate 
• 5329-14-6 aminosulfonic acid 
• 75-44-5 phosgene 

Downstream Products

• 33373-92-1 2-amino-3-chloro-N-thiazol-2-yl-benzamide 
• 144155-41-9 5-Chloro-3-(2,4-dichloro-phenyl)-1-[(E)-3-dimethylamino-propylimino]-1,3,4,10-tetrahydro-2H-acridin-9-one 
• 77820-58-7 methyl 3-chloroanthranilate 
• 41632-04-6 methyl 6-chloroanthranilate 
• 1235480-81-5 2-amino-N-(4-bromophenyl)-3-chlorobenzamide 
• 1464831-56-8 11-chloro-5-phenylindazolo[3,2-b]quinazolin-7-one 
• 1464831-43-3 2-(2-bromophenyl)-8-chloro-3-(phenylamino)-2,3-dihydroquinazolin-4(1H)-one 
• 110552-64-2 2-Amino-3-chloro-N-(5-imidazol-1-yl-pentyl)-benzamide 
• 18343-46-9 2-Amino-3-chloro-N-ethyl-benzamide 
• 18343-44-7 2-amino-3-chloro-benzamide 

Relevant articles and documents

Design, Synthesis, and Mechanism of Antiviral Acylurea Derivatives Containing a Trifluoromethylpyridine Moiety

Novel acylurea derivatives 7a-7ab were designed and synthesized by linking the active substructures trifluoromethylpyridine and anthranilic diamide via an acylurea bridge. Most of the title compounds exhibited good activity against tobacco mosaic virus (TMV), particularly compound 7x (EC50 of 211.8 μg/mL), which showed much higher curative activity than ningnanmycin (EC50 of 389.8 μg/mL), and compound 7ab, which showed excellent inactivation activity (EC50 of 36.1 μg/mL), similar to ningnanmycin (EC50 of 23.2 μg/mL). The preliminary mechanism of these derivatives was investigated. Autodocking analysis revealed that compounds 7x and 7ab had good affinity for TMV coat protein (TMV CP), with low binding energies (-7.86 and -8.59 kcal/mol) comparable to ningnanmycin (-8.75 kcal/mol). Molecular dynamics simulation showed that compound 7x had a stable system structure with a better binding free energy (-32.94 kcal/mol) than ningnanmycin (-25.62 kcal/mol). Microscale thermophoresis showed that compound 7x bound more strongly to TMV CP (Kd of 19.8 ± 7.3 μM) than ningnanmycin (Kd of 21.2 ± 7.3 μM). Transmission electron microscopy and self-assembly experiments demonstrated that compounds 7x and 7ab significantly obstructed the self-assembly of TMV RNA and TMV CP. This new acylurea derivative has excellent antiviral activity by targeting TMV CP and inhibiting TMV self-assembly and can be considered a candidate for antiviral applications.

New spiro pyrrole[2, 1-b]quinazolone derivative, preparation method and application thereof

The invention relates to a new spiro pyrrole[2, 1-b]quinazolone derivative, a preparation method and application thereof. The new spiro pyrrole[2, 1-b]quinazolone derivative is synthesized by using asimple method. The yield is high, the production cost is

Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one containing 4,5-dihydrothiazole-2-thiol derivatives against Meloidogyne incognita

A series of novel 1,2,3-benzotriazin-4-one derivatives containing 4,5-dihydrothiazole-2-thiol were synthesized and characterized by 1H NMR, 13C NMR, 19F NMR and HRMS. The bioassay results showed that compounds 3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)-7-methoxybenzo[d][1–3]triazin-4(3H)-one, 3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)-6-nitrobenzo[d][1–3]triazin-4(3H)-one, 7-chloro-3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)benzo[d][1–3]triazin-4(3H)-one exhibited good control efficacy against the cucumber root-knot nematode disease caused by Meloidogyne incognita at the concentration of 10.0 mg L?1 in vivo. Compound 7-chloro-3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)benzo[d][1–3]triazin-4(3H)-one showed excellent nematicidal activity with inhibition 68.3% at a concentration of 1.0 mg L?1. It suggested that the structure of 1,2,3-benzotriazin-4-one containing 4,5-dihydro-thiazole-2-thiol could be optimized further.