63497-60-9

Usage

Uses

Used in Research and Diagnostic Applications:
IFLAB-BB F1962-0261 is used as a research and diagnostic tool for studying the role of thiol oxidation in various disease states, such as cancer, cardiovascular disease, and neurodegenerative disorders. Its ability to selectively label and detect thiol groups helps in understanding the role of thiols in biological processes and disease mechanisms.
Used in Redox Biology Studies:
IFLAB-BB F1962-0261 is used as a fluorescent probe for investigating redox biology, providing insights into the redox status of cells and tissues and the role of thiol oxidation in cellular processes.
Used in Detection of Oxidative Stress:
IFLAB-BB F1962-0261 is used as a sensitive indicator for detecting oxidative stress in cells and tissues, allowing researchers to monitor the effects of oxidative stress on cellular function and health.
Used in Disease Mechanism Studies:
IFLAB-BB F1962-0261 is used as a tool for studying the role of thiol oxidation in the development and progression of various diseases, including cancer, cardiovascular disease, and neurodegenerative disorders. Its ability to selectively label and detect thiol groups aids in understanding the underlying mechanisms of these diseases and identifying potential therapeutic targets.

InChI:InChI=1/C8H4ClNO3/c9-5-3-1-2-4-6(5)10-8(12)13-7(4)11/h1-3H,(H,10,12)

Upstream product

• 7477-63-6 7-chloroisatin 
• 75-44-5 phosgene 
• 6388-47-2 2-amino-3-chlorobenzoic acid 
• 63498-13-5 N-ethoxycarbonyl-3-chloro-anthranilic acid 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 51108-30-6 4-chloro-1H-isoindole-1,3(2H)-dione 
• 117-21-5 3-chlorophthalic anhydride 
• 126-71-6 triisobutyl phosphate 
• 5329-14-6 aminosulfonic acid 

Downstream Products

• 77820-58-7 methyl 3-chloroanthranilate 
• 1235480-81-5 2-amino-N-(4-bromophenyl)-3-chlorobenzamide 
• 1464831-56-8 11-chloro-5-phenylindazolo[3,2-b]quinazolin-7-one 
• 1464831-43-3 2-(2-bromophenyl)-8-chloro-3-(phenylamino)-2,3-dihydroquinazolin-4(1H)-one 
• 18343-44-7 2-amino-3-chloro-benzamide 
• 41632-04-6 methyl 6-chloroanthranilate 
• 144155-41-9 5-Chloro-3-(2,4-dichloro-phenyl)-1-[(E)-3-dimethylamino-propylimino]-1,3,4,10-tetrahydro-2H-acridin-9-one 
• 110552-64-2 2-Amino-3-chloro-N-(5-imidazol-1-yl-pentyl)-benzamide 
• 33373-92-1 2-amino-3-chloro-N-thiazol-2-yl-benzamide 

Relevant academic research and scientific papers

Design, Synthesis, and Mechanism of Antiviral Acylurea Derivatives Containing a Trifluoromethylpyridine Moiety

Novel acylurea derivatives 7a-7ab were designed and synthesized by linking the active substructures trifluoromethylpyridine and anthranilic diamide via an acylurea bridge. Most of the title compounds exhibited good activity against tobacco mosaic virus (TMV), particularly compound 7x (EC50 of 211.8 μg/mL), which showed much higher curative activity than ningnanmycin (EC50 of 389.8 μg/mL), and compound 7ab, which showed excellent inactivation activity (EC50 of 36.1 μg/mL), similar to ningnanmycin (EC50 of 23.2 μg/mL). The preliminary mechanism of these derivatives was investigated. Autodocking analysis revealed that compounds 7x and 7ab had good affinity for TMV coat protein (TMV CP), with low binding energies (-7.86 and -8.59 kcal/mol) comparable to ningnanmycin (-8.75 kcal/mol). Molecular dynamics simulation showed that compound 7x had a stable system structure with a better binding free energy (-32.94 kcal/mol) than ningnanmycin (-25.62 kcal/mol). Microscale thermophoresis showed that compound 7x bound more strongly to TMV CP (Kd of 19.8 ± 7.3 μM) than ningnanmycin (Kd of 21.2 ± 7.3 μM). Transmission electron microscopy and self-assembly experiments demonstrated that compounds 7x and 7ab significantly obstructed the self-assembly of TMV RNA and TMV CP. This new acylurea derivative has excellent antiviral activity by targeting TMV CP and inhibiting TMV self-assembly and can be considered a candidate for antiviral applications.

Dihydroquinoline compound and preparation method and application thereof

The invention belongs to the field of medical chemistry, relates to a dihydroquinoline compound and a preparation method and application thereof, and particularly provides a compound as shown in a formula (I) or stereoisomers, salts, solvates and crystals thereof, a preparation method of the compound, and application of the compound serving as an intermediate in preparation of medicines for treating cancers or infectious diseases. The compound provided by the invention has the advantages of high yield, purity and optical purity in preparation of medicines for treating cancers or infectious diseases, mild reaction conditions, easiness in purification, stable process and easiness in operation, and can meet industrial-scale production and application.

New spiro pyrrole[2, 1-b]quinazolone derivative, preparation method and application thereof

The invention relates to a new spiro pyrrole[2, 1-b]quinazolone derivative, a preparation method and application thereof. The new spiro pyrrole[2, 1-b]quinazolone derivative is synthesized by using asimple method. The yield is high, the production cost is

Synthesis and structure-insecticidal activity relationship of novel phenylpyrazole carboxylic acid derivatives containing fluorine moiety

A series of novel phenylpyrazole carboxylic acid derivatives containing fluorine moiety, i.e., diamides 11, simple aryl-bearing amides 12 and acylthioureas 14 were successfully synthesized based on the key fluoro-containing phenylpyrazole acid intermediate. The new compounds were identified and confirmed by melting point, 1H NMR, 13C NMR and elemental analysis or HRMS. The bioassay results indicated that some of the compounds possessed excellent insecticidal activities towards oriental armyworm, diamondback moth and corn borer at low concentrations. For examples, compounds 11a, 11e?g and 14b exhibited remarkable larvicidal activities with LC50 values of 0.13 ? 0.39 mg/L and 0.0002 ? 0.0014 mg/L against oriental armyworm and diamondback moth, respectively, were comparable with those of the control chlorantraniliprole. Particularly, 11e were found superior to chlorantraniliprole in oriental armyworm tests (LC50: 0.23 mg/L vs. 0.26 mg/L); 11a, 11e, 11f and 14c in diamondback moth tests with LC50 values of 0.0002 mg/L, 0.0002 mg/L, 0.0008 mg/L and 0.0005 mg/L, respectively, were more effective than that of chlorantraniliprole. In addition, 12a also showed a promising insecticidal potential and development/optimization advantage. Compounds 11a, 11e–g, 12a, 14b and 14c could be considered as possible new leading structures for further study. The SAR investigation indicated that the compounds with fluorine motif (e.g., -F, -CF2H, -CF3) held apparently favorable insecticidal potentials, which provided useful guidance for further design/development of new phenylpyrazole-containing agrochemicals.

Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one containing 4,5-dihydrothiazole-2-thiol derivatives against Meloidogyne incognita

A series of novel 1,2,3-benzotriazin-4-one derivatives containing 4,5-dihydrothiazole-2-thiol were synthesized and characterized by 1H NMR, 13C NMR, 19F NMR and HRMS. The bioassay results showed that compounds 3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)-7-methoxybenzo[d][1–3]triazin-4(3H)-one, 3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)-6-nitrobenzo[d][1–3]triazin-4(3H)-one, 7-chloro-3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)benzo[d][1–3]triazin-4(3H)-one exhibited good control efficacy against the cucumber root-knot nematode disease caused by Meloidogyne incognita at the concentration of 10.0 mg L?1 in vivo. Compound 7-chloro-3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)benzo[d][1–3]triazin-4(3H)-one showed excellent nematicidal activity with inhibition 68.3% at a concentration of 1.0 mg L?1. It suggested that the structure of 1,2,3-benzotriazin-4-one containing 4,5-dihydro-thiazole-2-thiol could be optimized further.

Synthesis and nematicidal evaluation of 1,2,3-benzotriazin-4-one derivatives containing piperazine as linker against Meloidogyne incognita

To explore new skeleton with nematicidal activity, a series of novel 1,2,3-benzotriazin-4-one derivatives containing piperazine as linker were synthesized and varied fragments were also introduced to increase structure diversity of the new skeleton. Their inhibitory activities in vivo were evaluated against Meloidogyne incognita. The newly prepared compounds A6, A8, A21, A28 and A38 exhibited more than 50% inhibition at the concentration of 20 mg/L. Especially compound A6 displayed 71.4% inhibition against Meloidogyne incognita at the concentration of 20 mg/L. The nematicidal activities varied significantly depending on the types and positions of the substituents, which provided guidance for further structure modification.

Substituted pyrimidine type compound as well as preparation method and use thereof

The invention belongs to the medical chemistry field and particularly relates to a substituted pyrimidine type compound, a preparation method thereof and use thereof as a reference substance for the qualitative and/or quantitative analysis of relevant impurities in quality research of a raw material drug of mesylate of (S)-4-amino-6-((1-(8-chloro-4-oxo-2-phenyl-1,4-dihydroquinolin-3-yl)ethyl)amino)pyrimidine-5-cyano.

Substituted pyrimidines PI3K inhibitor a sulfonate of the crystal and its preparation method (by machine translation)

The invention belongs to the field of medicinal chemistry, relates to substituted pyrimidines PI3K inhibitors of a sulfonate of the crystal and its preparation method, in particular of the formula I (S)- 4 - amino - 6 - ((1 - (8 - chloro - 4 - oxo - 2 - phenyl - 1, 4 - dihydroquinoline - 3 - yl) ethyl) amino) pyrimidine - 5 - cyano methanesulfonic acid salt of crystal form and its preparation method, the methanesulfonic acid salt of the crystalline form can be used for preparing and treating and/or preventing cancer, tissue hyperplasia or inflammatory disease, (by machine translation)

Officinal salts of substituted pyrimidine type PI3K inhibitor and preparation method of officinal salt

The invention belongs to the medical chemistry field and relates to officinal salts, hydrates, solvates or crystals of a substituted pyrimidine type PI3K inhibitor and a preparation method and application of the officinal salts, the hydrates, the solvates or the crystals. The invention particularly relates to the officinal salts, hydrates, solvates or crystals of (S)-4-amino-6-((1-(8-chloro-4-oxo-2-phenyl-1,4-dihydroquinolin-3-yl)ethyl)amino)pyrimidine-5-cyano of formula (I) (shown in the description) and a preparation method of the officinal salts, the hydrates, the solvates or the crystals.The officinal salts, the hydrates, the solvates or the crystals can be used for preparing drugs for treating and/or preventing cancers, hyperblastosis or inflammatory diseases.

Acyl thiourea and acyl urea derivatives containing trifluoromethylpyridine and application thereof

The invention discloses acyl thiourea and acyl urea derivatives containing trifluoromethylpyridine and an application thereof. A structure of the derivatives is shown in a general formula I. In the formula, definitions of R1, R2, R3, X and other groups are as shown in the description. The compound represented by the general formula I has excellent insecticidal activity, and can be used to preventand treat pests such as cotton bollworm, diamondback moth and brown planthopper, and can also be used to prevent and treat plant virus diseases such as TMV and CMV.