63521-15-3

Usage

Therapeutic Function

Antibiotic

InChI:InChI=1/C18H15Cl2N5O5S3/c1-7-22-23-18(33-7)32-6-8-5-31-16-12(15(28)25(16)13(8)17(29)30)21-11(26)4-24-2-9(19)14(27)10(20)3-24/h2-3,12,16H,4-6H2,1H3,(H,21,26)(H,29,30)

Upstream product

• 63760-59-8 7-aminocephalosporanic acid 
• 107447-96-1 7-phenylacetylamino-3-(2-methyl-1,3,4-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid p-methoxybenzyl ester 
• 30246-33-4 (6R,7R)-7-amino-3-(5-methyl-1,3,4-thiadiazol-2-ylthiomethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 70149-51-8 3,5-Dichlor-4-pyridon-1-yl-ethylacetat 
• 957-68-6 7-Aminocephalosporanic acid 
• 56187-47-4 cefazedone 

Relevant academic research and scientific papers

Synthesis process of cefazedone sodium

The invention relates to a synthesis process of cefazedone sodium, which is characterized in that a thioester compound synthesized by taking 3,5-dichloro-4-pyridone-1-acetic acid and 2-sulfydryl-5-methyl-1,3,4-thiadiazole as raw materials is directly subjected to a one-step reaction with 7-ACA to prepare the cefazedone sodium. The process has the advantages of simplified operation steps, mild production conditions, reduced generation of byproducts, simple production process, improved product yield and purity, reduced cost, small environmental pollution and better environmental friendliness, and enables the process to meet the requirements of industrialization.

CEFAZEDONE SODIUM NEW CRYSTAL FORMS AND METHOD FOR MANUFACTURING THE SAME

The present invention relates to a novel crystal form of cepovidone sodium and a process for producing the same. , It will be described below. The X-ray powder diffraction pattern according to the 5.108 ±0.2 ° present 10.244 ±0.2 ° invention 12.355 ±0.2 ° has a characteristic diffraction 13.383 ±0.2 ° peak 16.124 ±0.2 ° at 19.180 ±0.2 ° 20.740 ±0.2 °, 23.012 ±0.2 ° 2 θ and, in each section of. (by machine translation)

New crystal form of cefazedone sodium salt and preparation method of new crystal form

The invention relates to a new crystal form of cefazedone sodium salt and a preparation method of the new crystal form, in particular to a crystal form of cefazedone sodium salt. The X-ray powder diffraction pattern of the crystal form of cefazedone sodium salt has characteristic diffraction peaks at the following 2theta angles: 5.108+/-0.2 degrees, 10.244+/-0.2 degrees, 12.355+/-0.2 degrees, 13.383+/-0.2 degrees, 16.124+/-0.2 degrees, 19.180+/-0.2 degrees, 20.740+/-0.2 degrees and 23.012+/-0 .2 degrees.

Preparation technology of cefazedone sodium

The invention belongs to the technical field of medicine, and discloses a preparation technology of cefazedone sodium. 3,5-dichloropyridone acetic acid and pivaloyl chloride are taken as the raw materials to synthesize mixed acid anhydrides; and then cefazedone sodium is obtained after salt forming reactions between mixed acid anhydrides and an intermediate prepared from 7-aminocephalosporanic acid and thiol tetrazole. A mixed solvent is used in 3-substitution, the reaction becomes more stable and softer, the byproducts are reduced; in acylation reactions, mixed acid anhydrides are used, the activity is high, 7-acylation reactions are promoted, and thus the yield and purity of cefazedone sodium are high.

A head west spore alkone sodium synthetic method (by machine translation)

The invention belongs to the field of medical technology, discloses a head-west spore alkone sodium synthetic method. In order to 3, 5 - dichloro pyridone acetic acid and two sulfur thioalcohol thiazole as raw material synthetic active ester, with the 7 - amino cephalosporanic acid and mercapto tetrazole generated intermediate reaction, into west spore alkone sodium salt obtained by the head. The invention in 3 - substituted using mixed in the solvent, the reaction is more stable and smooth, reducing the generation of by-products, in the acylation reaction using the active ester, active high, conducive to the 7 - position of the acylation reaction, the resulting west spore alkone sodium yield and purity are relatively high. (by machine translation)

Preparation method of cefazedone sodium compound

The invention discloses a preparation method of a cefazedone sodium compound. 7-ACA and a compound III react to prepare a compound IV, and the compound IV and a compound V have an amidation reaction,and are salified and refined to obtain a competitive product of cefazedone sodium (I). The process route of the reaction is simple, the total yield and the purity are high, and the method is suitablefor industrial production.

Cephalosporins anti-infective drug preparation method

The invention relates to a preparation method for a cephalosporin anti-infective drug-cefazedone sodium, belonging to the field of pharmaceutical synthesis. According to the invention, the method uses GCLE as a raw material to substitute 7-ACA and overcomes the defects of low yield, high pollution and the like in prior art; the preparation method with mild reaction conditions, little side reaction and simple process is provided; meanwhile, the method has the advantages of cheap and easily-available raw materials, low cost, high product yield, high product purity and applicability to industrial production.

Cephalosporins anti-infection drugs synthesis process

The invention relates to a synthetic process of a novel cephalosporin anti-infective drug. A thioester compound (formula III) synthesized by adopting 3,5-dichloro-4-pyridone-1-acetic acid and 2-thiol-5-methyl-1,3,4-thiadiazole as raw materials is directly reacted with 7-ACA in one step to successfully prepare cefazedone sodium. According to the synthetic process disclosed by the invention, the operating steps are simplified, so that the production conditions are milder, the generation of byproducts is reduced, and the production technology is simpler; and moreover, the product yield and purity are greatly improved, the cost is reduced, the environmental pollution is little, and the synthetic process is higher in environmental protection, so that the process accords with the requirement of industrialization.