63529-30-6

Basic information

• Product Name: 2-BROMO-3'-CHLORO-4'-FLUOROACETOPHENONE, 96%
• Synonyms: 2-Bromo-1-(3-chloro-4-fluorophenyl)ethanone, 3μ-Chloro-4μ-fluorophenacyl bromide;3-Chloro-4-fluorophenacyl bromide 98%;2-Bromo-3'-chloro-4'-fluoroacetophenone, 2-Bromo-1-(3-chloro-4-fluorophenyl)ethan-1-one;2-Bromo-3'-chloro-4'-fluoroacetophenone 96%;3-Chloro-4-fluorophenacylbromide98%
• CAS NO: 63529-30-6
• Molecular Formula: C₈H₅BrClFO
• Molecular Weight: 251.49
• Mol File: 63529-30-6.mol

Chemical Properties

• Melting Point: 33-36 °C
• Boiling Point: 303.6°C at 760 mmHg
• Flash Point: 110 °C
• Appearance: /Solid
• Density: 1.673g/cm³
• Vapor Pressure: 0.000919mmHg at 25°C
• Refractive Index: 1.564
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-BROMO-3'-CHLORO-4'-FLUOROACETOPHENONE, 96%(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-3'-CHLORO-4'-FLUOROACETOPHENONE, 96%(63529-30-6)
• EPA Substance Registry System: 2-BROMO-3'-CHLORO-4'-FLUOROACETOPHENONE, 96%(63529-30-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 63529-30-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-BROMO-3'-CHLORO-4'-FLUOROACETOPHENONE, 96% is used as a chemical intermediate for the synthesis of pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Chemical Industry:
In the chemical industry, 2-BROMO-3'-CHLORO-4'-FLUOROACETOPHENONE, 96% is used as a reagent in organic synthesis. Its versatility in chemical reactions enables the production of a wide range of organic compounds for various applications.
Used in Medicinal Chemistry Research:
2-BROMO-3'-CHLORO-4'-FLUOROACETOPHENONE, 96% is employed as a research reagent in medicinal chemistry. Its properties and reactivity are studied to understand its potential role in the development of new pharmaceutical agents and to explore its interactions with biological targets.

InChI:InChI=1/C8H5BrClFO/c9-4-8(12)5-1-2-7(11)6(10)3-5/h1-3H,4H2

Upstream product

• 403-16-7 3-chloro-4-fluorobenzoic acid 
• 144-55-8 sodium hydrogencarbonate 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 34328-61-5 3-Chloro-4-fluorobenzaldehyde 
• 2923-66-2 3-chloro-4-fluoroacetophenone 

Downstream Products

• 1352633-44-3 (R)-1-(2-(3-chloro-4-fluorophenyl)-2-oxoethyl)-3-((R)-2-phenyl-2-(phenylamino)acetoxy)-1-azoniabicyclo[2.2.2]octane bromide 
• 78864-23-0 (4-bromo-phenyl)-[5-(3-chloro-4-fluoro-phenyl)-thiazol-2-yl]-amine 
• 1374002-56-8 1-(3-chloro-4-fluorophenyl)-2-hydroxyethan-1-one 

Relevant articles and documents

2-OXO-OXAZOLIDINE-5-CARBOXAMIDES AS NAV1.8 INHIBITORS

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.

2-OXOIMIDAZOLIDINE-4-CARBOXAMIDES AS NAV1.8 INHIBITORS

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.

Selective Debromination of α,α,α-Tribromomethylketones with HBr–H2O Reductive Catalytic System

A debromination of α,α,α-tribromomethylketones is developed for chemoselective synthesis of α-mono- and α,α-dibromomethylketones with high selectivity under H2O–HBr reductive conditions. This method offers an efficient and direct way to synthesize α-mono or α,α-dibromomethylketone compounds in high to excellent yields through the process of HBr self-circulation in water.

SUBSTITUTED (THIAZOLYL-CARBONYL)IMIDAZOLIDINONES AND USE THEREOF

The present invention relates to novel substituted furancarboxamides, methods for their production, their use for the treatment and/or prevention of diseases, as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially retroviral diseases, in humans and/or animals.

Diarylspiro[2.4]heptenes as orally active, highly selective cyclooxygenase-2 inhibitors: Synthesis and structure-activity relationships

A novel series of 5,6-diarylspiro[2.4]hept-5-enes was shown to provide highly potent and selective cyclooxygenase-2 (COX-2) inhibitors. A study of structure-activity relationships in this series suggests that 3,4- disubstituted phenyl analogs are generally more selective than 4-substituted phenyl analogs and that replacement of the methyl sulfone group on the 6- phenyl ring with a sulfonamide moiety results in compounds with superior in vivo pharmacological properties, although with lower COX-2 selectivity. Several compounds have been shown to possess promising pharmacological properties in adjuvant-induced arthritis and edema analgesia models. The absence of gastrointestinal (GI) toxicity at 200 mpk of several selected compounds in rats and mice corresponds well with the weak potency for inhibition of COX-1 observed in the enzyme assay. Methyl sulfone 55 and sulfonamide 24 were shown to have superior in vivo pharmacological profiles, low GI toxicity, and good oral bioavailability and duration of action.

Synthesis of some New Fluorine containing Oxazoles, Oxadiazoles, Thiadiazoles and Triazines

Treatment of fluorine containing phenacyl bromides with urea or substituted arylureas afforded the corresponding 2-(amino/N-arylamino)-4-(fluoroaryl)oxazoles, and with ammonium acetate in glacial acetic acid yielded 2-methyl-4-(fluoroaryl)oxazoles.Fluorin