635291-70-2

Upstream product

• 635291-65-5 (S)-3-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-pyrazolidine-1-carboxylic acid benzyl ester 
• 635291-69-9 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpent-4-enoic acid 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 635291-76-8 methyl (3S)-2-[(2S,3S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenyl-5-oxopentanoyl]-1-benzyloxycarbonylpyrazolidine-3-carboxylate 
• 635291-78-0 (S)-2-[(2S,3S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-5-hydroxy-3-phenyl-pentanoyl]-pyrazolidine-1,3-dicarboxylic acid 1-benzyl ester 3-methyl ester 

Relevant academic research and scientific papers

Constrained peptidomimetics: Building bicyclic analogs of pyrazoline derivatives

A synthetic route has been developed for incorporating pyrazoline derivatives as proline surrogates in constrained X-Pro peptidomimetics. The route allows for the synthesis of dipeptide building blocks having either a six or seven-membered-ring annulated