635680-13-6

Upstream product

• 87967-95-1 5-methyl-3-phenylisoxazole-4-carboxaldehyde 
• 292638-85-8 acrylic acid methyl ester 
• 2065-28-3 methyl 5-methyl-3-phenylisoxazole-4-carboxylate 
• 698-16-8 benzohydroximoyl chloride 
• 18718-79-1 5-methyl-3-phenyl-4-isoxazolylmethanol 

Downstream Products

• 798555-70-1 2-[acetoxy-(5-methyl-3-phenyl-isoxazol-4-yl)-methyl]-acrylic acid methyl ester 
• 95514-24-2 (Z)-1-amino-1-phenyl-1-buten-3-one 
• 798555-49-4 5-acetyl-3-methyl-6-phenyl-1H-pyridin-2-one 
• 884537-20-6 2-[2-acetyl-1-(5-methyl-3-phenylisoxazol-4-yl)-3-oxobutyl]acrylic acid methyl ester 
• 1189021-38-2 methyl 5-[hydroxy-(5-methyl-3-phenylisoxazol-4-yl)methyl]-3-(2-nitrophenyl)-4,5-dihydroisoxazole-5-carboxylate 

Relevant academic research and scientific papers

Tributyltin hydride-mediated straightforward synthesis of a new isoxazolo-benzazulene ring system

Tributyltin hydride-mediated straightforward synthesis of a new isoxazolo-benzazulene system from the derivatives afforded by the Baylis-Hillman reaction of 3-(2-bromophenyl)-4-isoxazolecarbaldehydes is described.

Highly substituted isoxazoles: The Baylis-Hillman reaction of substituted 4-isoxazolecarbaldehydes and attempted cyclization to isoxazole-annulated derivatives

In an attempt to understand the effect of position of the formyl group on the efficiency of Baylis-Hillman reaction within isoxazolecarbaldehydes, the reactions of substituted 4-isoxazolecarbaldehydes to obtain highly substituted isoxazoles are described. Attempts to obtain isoxazole-annulated derivatives from these Baylis-Hillman adducts involving SNR′-SNAr substitution strategy are also described.