635728-14-2

Upstream product

• 230287-23-7 N-(1,4-dioxaspiro[4.5]decyl-7-idene)benzylamine 
• 635728-13-1 4-allyl-4-benzylaminocyclohexanone ethylene acetal 

Downstream Products

• 1025864-77-0 (9-benzyl-1,4-dioxa-9-aza-dispiro[4.2.4.2]tetradec-11-yl)-methyl-amine 
• 1202072-51-2 9-benzyl-1,4-dioxa-9-aza-dispiro[4.2.4.2]tetradecane 
• 1202072-53-4 trans-1-benzyl-1-aza-spiro[4.5]decan-8-ol 
• 1202072-52-3 1-benzyl-1-aza-spiro[4.5]decan-8-one 
• 635728-15-3 1-benzyl-3-(N-methyl-N-methoxycarbonyl)amino-1-azaspiro[4.5]decan-8-one ethylene acetal 

Relevant academic research and scientific papers

Synthesis of enantiopure 1-azaspiro[4.5]decanes by iodoaminocyclization of allylaminocyclohexanes

The 5-endo iodine-promoted ring closure of 4-allyl-4-(alkylamino) cyclohexanone derivatives gives the corresponding 1-azaspiro[4.5]decanes in good yields. The reaction was tested with enantiopure homoallylamines to evaluate the diastereoselectivity of the process and to provide a route for possible intermediates to the natural products embodying this azabicyclic ring. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.

A new synthetic entry to the tricyclic skeleton of FR901483 by palladium-catalyzed cyclization of vinyl bromides with ketone enolates

A new synthetic entry to the FR901483 core is described. The Pd-mediated cyclization of amino-tethered vinyl halides and ketone enolates from the azaspiro[4.5]decan-8-ones 5 and 10 gives the functionalized 7,10a-methanoperhydropyrrolo[1,2-a]azocines 1 and 11, respectively.