635728-15-3

Upstream product

• 635728-14-2 1-benzyl-3-iodo-1-azaspiro[4.5]decan-8-one ethylene acetal 
• 635728-13-1 4-allyl-4-benzylaminocyclohexanone ethylene acetal 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 79-22-1 methyl chloroformate 
• 1025864-77-0 (9-benzyl-1,4-dioxa-9-aza-dispiro[4.2.4.2]tetradec-11-yl)-methyl-amine 

Relevant academic research and scientific papers

Atom transfer radical cyclization of trichloroacetamides to electron-rich acceptors using Grubbs' catalysts: Synthesis of the tricyclic framework of FR901483

Intramolecular Kharasch-type additions of trichloroacetamides on anisole and enol acetates catalyzed by Grubbs' ruthenium carbenes are described. This protocol provides access to highly functionalized 2-azaspiro[4.5]decanes, morphan compounds, and the aza

A new synthetic entry to the tricyclic skeleton of FR901483 by palladium-catalyzed cyclization of vinyl bromides with ketone enolates

A new synthetic entry to the FR901483 core is described. The Pd-mediated cyclization of amino-tethered vinyl halides and ketone enolates from the azaspiro[4.5]decan-8-ones 5 and 10 gives the functionalized 7,10a-methanoperhydropyrrolo[1,2-a]azocines 1 and 11, respectively.