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63586-82-3

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63586-82-3 Usage

General Description

1-oxo-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid, also known as SALTDATA: FREE, is a chemical compound that belongs to the class of isoquinoline carboxylic acids. It is a white crystalline powder with a molecular formula C10H9NO3 and a molecular weight of 191.18 g/mol. This chemical is often used in pharmaceutical research and drug synthesis due to its potential therapeutic properties. It is also used as a building block for the synthesis of various bioactive molecules. Additionally, this compound has been studied for its potential role in the treatment of neurological disorders and as an anti-inflammatory agent. Overall, 1-oxo-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid has promising applications in the pharmaceutical and medical fields.

Check Digit Verification of cas no

The CAS Registry Mumber 63586-82-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,5,8 and 6 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 63586-82:
(7*6)+(6*3)+(5*5)+(4*8)+(3*6)+(2*8)+(1*2)=153
153 % 10 = 3
So 63586-82-3 is a valid CAS Registry Number.

63586-82-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-oxo-3,4-dihydro-2H-isoquinoline-3-carboxylic acid

1.2 Other means of identification

Product number -
Other names 1-oxo-1,2,3,4-tetrahydro-3-isoquinoline carboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:63586-82-3 SDS

63586-82-3Relevant articles and documents

Design, synthesis, and in vitro evaluation of potential west nile virus protease inhibitors based on the 1-oxo-1,2,3,4-tetrahydroisoquinoline and 1-oxo-1,2-dihydroisoquinoline scaffolds

Dou, Dengfeng,Viwanathan, Prasanth,Li, Yi,He, Guijia,Alliston, Kevin R.,Lushington, Gerald H.,Brown-Clay, Joshua D.,Padmanabhan,Groutas, William C.

experimental part, p. 836 - 843 (2011/01/13)

The 1-oxo-1, 2, 3, 4-tetrahydroisoquinoline and 1-Oxo-1, 2-dihydroisoquinoline scaffolds were utilized in the design and solution phase synthesis of focused libraries of compounds for screening against West Nile Virus (WNV) protease. Exploratory studies have led to the identification of a WNV protease inhibitor (a 1-oxo-1, 2-dihydroisoquinoline-based derivative, 12j) which could potentially serve as a launching pad for a hit-to-lead optimization campaign. The identified hit was devoid of any inhibitory activity toward a panel of mammalian serine proteases.

BENZOTHIAZO AND RELATED HETEROCYCLIC GROUP-CONTAINING CYSTEINE AND SERINE PROTEASE INHIBITORS

-

, (2008/06/13)

The present invention is directed to novel benzothiazo and related heterocyclic group-containing inhibitors of cysteine or serine proteases. Methods for using the same are also described.

Ibotenic acid analogues. Synthesis and biological and in vitro activity of conformationally restricted agonists at central excitatory amino acid receptors

Krogsgaard-Larsen,Nielsen,Curtis

, p. 585 - 591 (2007/10/02)

A number of analogues of ibotenic acid [(RS)-3-hydroxy-5-isoxazoleglycine] were synthesized; they were tested as excitants on neurons in the cat spinal cord, by using microelectrophoretic techniques, and as inhibitors of the binding of kainic acid (KA) in vitro, by using synaptic membranes prepared from rat brains. The excitatory effects of the 3-isoxazolol amino acids (RS)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-7-carboxylic acid (4, 7-HPCA), (RS)-α-amino-3-hydroxy-5,6-dihydro-4H-cyclohept[1,2-d]isoxazole-8-propion ic acid (8, 8-AHCP), (RS)-α-amino-3-hydroxy-7,8-dihydro-6H-cyclohept[1,2-d]isoxazole-4-propion ic acid (12, 4-AHCP), and (RS)-α-(methylamino)-3-hydroxy-5-methyl-4-isoxazolepropionic acid (N-Me-AMPA) were shown to be sensitive to (S)-glutamic acid diethyl ester (GDEE), an antagonist at quisqualic acid (QUIS) receptors, and insensitive to (RS)-2-amino-5-phosphonovaleric acid (2APV), an antagonist at N-methyl-(R)-aspartic acid (NMDA) receptors. The compounds 4 and 12 proved to be particularly potent agonists at the former class of receptor, assumed to represent physiological glutamic acid receptors. The amino acids (RS)-β-(2-carboxyphenyl)alanine (19), an analogue of 12, and (RS)-2-(3-carboxyphenyl)glycine were weak GDEE-sensitive excitants with potencies comparable with that of 8. All of the compounds were tested as inhibitors of KA binding. With the exception of 12 and 19, which showed very low affinity for the KA binding sites, the compounds studied were inactive in this in vitro test system.

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