63592-85-8

Usage

Uses

Methyl 4-chloronicotinate, HCl

InChI:InChI=1/C7H6ClNO2/c1-11-7(10)5-4-9-3-2-6(5)8/h2-4H,1H3

Upstream product

• 67-56-1 methanol 
• 10177-29-4 4-chloronicotinic acid 
• 100791-00-2 4-chloronicotinoyl chloride 
• 68-12-2 N,N-dimethyl-formamide 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 74-88-4 methyl iodide 
• 186581-53-3 diazomethane 

Downstream Products

• 151322-66-6 methyl 4-biphenyl-4-yl>methyl>amino>pyridine-3-carboxylate 
• 1055897-41-0 methyl 4-(benzylamino)nicotinate 
• 1387572-95-3 2-{[2-bromo-4-(trifluoromethyl)phenyl]sulfonyl}-1,3,4,10b-tetrahydropyrido[4',3':3,4]pyrrolo[1,2-a]pyrazin-6(2H)-one 
• 1387568-72-0 2-{[4-(trifluoromethyl)phenyl]sulfonyl}-1,3,4,10b-tetrahydropyrido[4',3':3,4]pyrrolo[1,2-a]pyrazin-6(2H)-one 
• 1387568-74-2 2-{[2-methyl-4-(trifluoromethyl)phenyl]sulfonyl}-1,3,4,10b-tetrahydropyrido[4',3':3,4]pyrrolo[1,2-a]pyrazin-6(2H)-one 
• 189449-41-0 4-chloro-3-(hydroxymethyl)pyridine 

Relevant academic research and scientific papers

Unimolecular Anion-Binding Catalysts for Selective Ring-Opening Polymerization of O-carboxyanhydrides

Anion-binding can regulate anion transport in chloride channels through dynamic non-covalent interactions, which gives insights into the designing of new organocatalytic transformations but is surprisingly unexplored in polymerization catalysis. Herein, we describe an effective unimolecular anion-binding organocatalysis where 4-(dimethylamino)pyridine is anchored to a thiourea for ring-opening polymerization of O-carboxyanhydrides (OCAs) to furnish highly isotactic poly(phenyllactic acid) (Ph-PLA) with molecular weight (MW) up to 150.0 kDa, which well addresses the formidable challenge of synthesizing high MW stereoregular polyesters. Calculations and experimental studies indicate a dynamic cooperative anion-binding mechanism, where the dynamic anion-binding interaction of thiourea moiety to propagating species facilitates efficient chain propagation and the synergetic decarboxylation retains high selectivity for OCA ring-opening over side reactions (such as cyclization, epimerization, and transesterification).

DMAP-thiourea catalyst and preparation method thereof, and high-molecular-weight biodegradable polyester and preparation method thereof

The invention relates to a DMAP-thiourea catalyst and a preparation method thereof as well as high-molecular-weight biodegradable polyester and a preparation method thereof. The DMAP-thiourea catalyst disclosed by the invention has the characteristic of living polymerization when being used for catalyzing ring opening polymerization of O-carboxyl anhydride monomers (OCAs). According to the DMAP-thiourea catalyst disclosed by the invention, a thiourea group is used as Lewis acid, a monomer is activated through a hydrogen bond, DMAP is used as Lewis alkali and a nucleophilic addition monomer, and ring opening polymerization of an OCAs monomer is commonly catalyzed by utilizing an adjacent synergistic effect. Especially, the increased active species are zwitterions, and no alcohol is needed as an initiator. The polymerization speed is high, the reaction temperature is low, and the obtained polyester is high in molecular weight and narrow in distribution. By adjusting the structure of the catalyst, changing the acidity and alkalinity of the catalyst and the steric hindrance of the catalyst and optimizing parameters such as polymerization temperature, concentration and the like, controllable polymerization of the OCAs monomer is realized, and finally, biodegradable polyester with molecular weight as high as 130,000 is obtained.

BIPHENYL COMPOUND AS CCR2/CCR5 RECEPTOR ANTAGONIST

Provided is a CCR2/CCR5 receptor antagonist and the use thereof in the preparation of a drug for treating diseases associated with the CCR2/CCR5. In particular, disclosed are a compound represented by formula (I) and a pharmaceutically acceptable salt thereof

INDOLE DERIVATIVE USED AS CRTH2 INHIBITOR

The present application discloses an indole as represented by formula (I) used as a CRTH2 inhibitor, and a pharmaceutically acceptable salt or tautomer of the indole, and an application of same in treating a disease related to a CRTH2 receptor.

Indole derivative serving as CRTH2 inhibitor

The invention discloses an indole derivative serving as a CRTH2 inhibitor shown as a formula (I) as shown in the specification or pharmaceutically acceptable salts, as well as application of the indole derivative in treatment of diseases related to the CR

TRICYCLIC PYRI DO-CARBOXAM I D E DERIVATIVES AS ROCK INHIBITORS

The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates

ARYL LACTAM KINASE INHIBITORS

The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

Aryl vinyllactam serinekinase inhibitor

The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

ARYL ETHER-BASE KINASE INHIBITORS

The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

Aryl Ether-Base Kinase Inhibitors

The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.