63615-58-7

Basic information

• Product Name: 2-(morpholin-4-yl)-4-phenylquinazoline
• CAS NO: 63615-58-7
• Molecular Formula: C₁₈H₁₇N₃O
• Molecular Weight: 291.3471
• Mol File: 63615-58-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 496.6°C at 760 mmHg
• Flash Point: 254.1°C
• Density: 1.221g/cm³
• Vapor Pressure: 5.34E-10mmHg at 25°C
• Refractive Index: 1.646
• CAS DataBase Reference: 2-(morpholin-4-yl)-4-phenylquinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(morpholin-4-yl)-4-phenylquinazoline(63615-58-7)
• EPA Substance Registry System: 2-(morpholin-4-yl)-4-phenylquinazoline(63615-58-7)

Safety Data

• Hazardous Substances Data: 63615-58-7(Hazardous Substances Data)

Usage

General Description

2-(morpholin-4-yl)-4-phenylquinazoline is a chemical compound with the molecular formula C20H18N4O. It is a quinazoline derivative, meaning it contains a quinazoline ring structure. The compound also contains a morpholine group, which is a saturated heterocyclic amine. With a phenyl group attached to the quinazoline ring, this compound exhibits aromatic properties. It has potential applications in medicinal chemistry, as quinazoline derivatives have been studied for their antitumor, antifungal, and antiviral properties. Additionally, the morpholine group in the compound suggests potential biological activity, as morpholine derivatives have been utilized as pharmaceuticals and agrochemicals. Further research into the properties and potential uses of 2-(morpholin-4-yl)-4-phenylquinazoline could reveal its specific biological and pharmacological activities.

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Relevant articles and documents

Synthesis and Structure-Photophysics Evaluation of 2-N-Amino-quinazolines: Small Molecule Fluorophores for Solution and Solid State

2-N-aminoquinazolines were prepared by consecutive SNAr functionalization. X-ray structures display the nitrogen lone pair of the 2-N-morpholino group in conjugation with the electron deficient quinazoline core and thus representing electronic push-pull systems. 2-N-aminoquinazolines show a positive solvatochromism and are fluorescent in solution and in solid state with quantum yields up to 0.73. Increase in electron donor strength of the 2-amino substituent causes a red-shift of the intramolecular charge transfer (ICT) band (300–400 nm); whereas the photoluminescence emission maxima (350–450 nm) is also red-shifted significantly along with an enhancement in photoluminescence efficiency. HOMO-LUMO energies were estimated by a combination of electrochemical and photophysical methods and correlate well to those obtained by computational methods. ICT properties are theoretically attributed to an excitation to Rydberg-MO in SAC-CI method, which can be interpreted as n-π* excitation. 7-Amino-2-N-morpholino-4-methoxyquinazoline responds to acidic conditions with significant increases in photoluminescence intensity revealing a new turn-on/off fluorescence probe.

Efficient copper-catalyzed synthesis of 2-amino-4(3h)-quinazolinone and 2-aminoquinazoline derivatives

We have developed a versatile and efficient method for copper-catalyzed synthesis of both 2-amino-4(3H)-quinazolinone and 2-aminoquinazoline derivatives. The protocol uses readily available substituted 2-halobenzoic acids, 2-bromobenzaldehyde, 2-bromophen