29874-83-7

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-4-phenylquinazoline is used as a pharmaceutical intermediate for the synthesis of MTH1 inhibitors, which are potential cancer eradicators. These inhibitors target the enzyme MTH1, which is overexpressed in various cancer cells, leading to the disruption of cancer cell metabolism and ultimately, the eradication of cancer cells.
Used in Chemical Research and Development:
2-Chloro-4-phenylquinazoline serves as an organic synthesis intermediate, primarily utilized in the laboratory research and development process. It is a key component in the synthesis of various complex organic molecules and pharmaceutical compounds, contributing to the advancement of chemical production processes and the discovery of new therapeutic agents.

Synthesis

A 2 L flask was charged with 35.0 g (175.8 mmol) of 2,4-dichloroquinoline,22.5 g (184.6 mmol) of phenylboronic acid, 6.1 g (5.3 mmol) of tetrakis(triphenylphosphine)palladium(0) were added to 800 mL of tetrahydrofuran and 400 mL of water, and the mixture was heated to 60 ° C for 12 hours under a nitrogen stream. . The resulting mixture was added to methanol (3000 mL), and the crystallized solid was filtered and dissolved in toluene, filtered through silica gel / celite, and the organic solvent was removed in an appropriate amount, and then recrystallization from methanol gave Intermediate I-A52-1 (36.8 g, 87% yield).

InChI:InChI=1/C14H9ClN2/c15-14-16-12-9-5-4-8-11(12)13(17-14)10-6-2-1-3-7-10/h1-9H

Upstream product

• 6141-13-5 2-chloroquinazoline 
• 108-86-1 bromobenzene 
• 3740-92-9 fenclorim 
• 98-80-6 phenylboronic acid 
• 57-13-6 urea 
• 2835-77-0 (2-aminophenyl)(phenyl)methanone 
• 100-58-3 phenylmagnesium bromide 
• 1885-29-6 anthranilic acid nitrile 
• 607-68-1 2,4-dichloroquinazoline 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 23441-75-0 4-phenyl-1H-quinazolin-2-one 
• 591-51-5 phenyllithium 

Downstream Products

• 1904-72-9 3,4-dihydro-4-phenylquinazoline 
• 64820-60-6 2-hydrazino-4-phenyl-quinazoline 
• 100672-11-5 2-(3',5'-dimethyl-1'-pyrazolyl)-4-phenylquinazoline 
• 17629-09-3 2-Methoxy-4-phenylquinazoline 
• 139474-20-7 2-(Dimethylamino)-4-phenylquinazoline 
• 106824-02-6 N-(2'-dimethylaminoethyl)-4-phenylquinazolin-2-amine 
• 139474-22-9 Trimethyl(4-phenyl-2-quinazolinyl)ammonium chloride 
• 100672-16-0 4-Phenyl-2-(3,3,5-trimethyl-2,3-dihydro-pyrazol-1-yl)-quinazoline 
• 100672-13-7 5-Methyl-2-(4-phenyl-quinazolin-2-yl)-2,4-dihydro-pyrazol-3-one 
• 100672-18-2 5-Amino-2-(4-phenyl-quinazolin-2-yl)-1,2-dihydro-pyrazol-3-one 
• 100672-21-7 4-Phenyl-1-(4-phenyl-quinazolin-2-yl)-1H-pyrazol-3-ylamine 
• 17629-01-5 4-phenylquinazoline 
• 1365548-84-0 10-bromo-7-(4-phenylquinazolin-2-yl)-7H-benzo[c]carbazole 
• 1365548-86-2 C₃₀H₂₀BN₃O₂ 

Relevant academic research and scientific papers

Aromatic compound and organoelectroluminescent device comprising the compound

The present invention relates to an aromatic compound and an organic electroluminescent device including the same. The aromatic compound is represented by chemical formula 1, and the organic electroluminescent device is excellent in driving voltage, luminous efficiency and lifetime characteristics.

COMPOUND FOR AN ORGANIC ELECTRIC ELEMENT, AN ORGANIC ELECTRIC ELEMENT USING THE SAME, AND AN ELECTRONIC DEVICE THEREOF

The present invention provides the compound represented by Formula 1, an organic electric element comprising a first electrode, a second electrode, and an organic material layer formed between the first electrode and the second electrode, and electronic d

COMPOUND FOR ORGANIC ELECTRONIC ELEMENT, ORGANIC ELECTRONIC ELEMENT USING THE SAME, AND AN ELECTRONIC DEVICE THEREOF

The present invention relates to high luminous efficiency of a device. The present invention provides a compound capable of improving a low driving voltage and a lifespan, an organic electronic element using the same, and an electronic device thereof.

An electroluminescent compound and an electroluminescent device comprising the same

The present invention relates to an organic light emitting compound represented by chemical formula 1 and an organic electroluminescent device including the same, and the organic light emitting compound according to the present invention has excellent luminous efficiency and material lifetime properties, and thus, the organic electroluminescent device having excellent luminous efficiency while having power efficiency and long durability can be manufactured. Chemical formula 1.

Novel organic compounds for organic light-emitting diode and organic light-emitting diode including the same

The present invention relates to an organic light emitting compound represented by formula A and an organic light emitting diode including the same. Substituents A1 to A4, R1 to R17, X, Y, a, b, m, n, p, L1, and L2 are identical to as defined in the detailed description.

Novel organic compounds for organic light-emitting diode and organic light-emitting diode including the same

The present invention relates to an organic electroluminescent compound represented by chemical formula A, and an organic light emitting device comprising the same. Substituents A_1 to A_4, R_1 to R_15, X_1, X_2, Y, n, q, and L are the same as defined in the detailed description of the invention.

Carbazole derivatives and organoelectro luminescent device using the same

PURPOSE: A carbazole derivative is provided to drive an organic electroluminescent device at low voltage and to improve brightness when the derivative is used in an organic layer of the organic electroluminescent device, thereby improving economic efficiency. CONSTITUTION: A carbazole derivative is denoted by chemical formula 1. An organic electroluminescent device comprises a first electrode, a second electrode, and one or more organic layers between the first and second electrodes. The organic layers contain the carbazole derivative of chemical formula 1. The organic layers are selected among a hole injection layer, a hole transport layer, a functional layer with hole injecting and transporting functions, a light emitting layer, an electrode transport layer, and an electron injection layer. The light emitting layer contains one or more host compounds and one or more dopant compounds. The host compound is a carbazole derivative of chemical formula 1.

An organoelectro luminescent compounds and organoelectro luminescent device using the same

The present invention relates to an organic electroluminescent compound represented by chemical formula A) to [Chemical Formula C], and an organic electroluminescent device comprising the same. The organic light-emitting compound according to the present invention has low driving voltage and excellent luminous efficiency and lifetime characteristics. [Chemical Formula A] [formula C] [Chemical Formula C] (by machine translation)

Heterocyclic com pounds and organic light-emitting diode including the same

PURPOSE: A heterocyclic compound and an organic electroluminescent device containing the same are provided to have superior luminescent characteristics such as stability, light emitting efficiency, and lifetime with low driving voltage. CONSTITUTION: A heterocyclic compound is denoted by chemical formula 1. An organic electroluminescent device comprises a first electrode, a second electrode, and one or more organic layers between the first and second electrodes. The organic layers contain one or more heterocyclic compounds. The organic layers are selected among a hole injection layer, a hole transport layer, a functional layer with hole injecting and transporting functions, a light emitting layer, an electron transport layer, and an electron injection layer. The light emitting layer contains one or more host compounds and dopant compounds.

Heterocyclic com pounds and organic light-emitting diode including the same

The present invention relates to a novel heterocyclic compound and an organic electroluminescent device comprising the same. The heterocyclic compound is represented by the following Chemical Formula 1, and the organic electroluminescent device including the heterocyclic compound has excellent driving voltage, luminous efficiency, and lifespan properties. Chemical Formula 1. (by machine translation)