6362-61-4

Upstream product

• 6362-67-0 phenyl-oxalacetic acid-anhydride 
• 62-53-3 aniline 
• 156-06-9 2-oxo-3-(phenyl)propionic acid 
• 103-79-7 1-phenyl-acetone 
• 103-71-9 phenyl isocyanate 
• 582-61-6 benzoyl azide 
• 6458-42-0 4-benzyl-2,2-bis-trifluoromethyl-oxazolidin-5-one 
• 124337-51-5 9-(1-Benzotriazol-1-yl-2-phenyl-ethyl)-9H-carbazole 
• 203131-82-2 1-(1-Methylsulfanyl-2-phenyl-ethyl)-1H-benzotriazole 
• 136617-26-0 2-Benzotriazol-1-yl-2-carbazol-9-yl-3,N-diphenyl-propionamide 

Downstream Products

• 54746-64-4 N,2,3-triphenylacrylamide 
• 1255501-10-0 (3S,4R)-5-nitro-2-oxo-N,3,4-triphenylpentanamide 
• 1255501-12-2 (3S,4R)-4-(4-fluorophenyl)-5-nitro-2-oxo-N,3-diphenylpentanamide 
• 1255501-11-1 (3S,4R)-4-(4-methoxyphenyl)-5-nitro-2-oxo-N,3-diphenylpentanamide 
• 1255501-13-3 (3S,4R)-5-nitro-4-(4-nitrophenyl)-2-oxo-N,3-diphenylpentanamide 
• 1255501-14-4 (3S,4S)-4-(nitromethyl)-2-oxo-N,3,6-triphenylhexanamide 

Relevant academic research and scientific papers

Rapid assembly of α-ketoamides through a decarboxylative strategy of isocyanates with α-oxocarboxylic acids under mild conditions

A simple and practical method for α-ketoamide synthesis via a decarboxylative strategy of isocyanates with α-oxocarboxylic acids is described. The reaction proceeds at room temperature under mild conditions without an oxidant or an additive, showing good substrate scope and functional compatibility. Moreover, the applicability of this method was further demonstrated by the synthesis of various bioactive molecules and different application examples through a two-step one-pot operation.

Synthetic method of alpha-keto amide compound

The invention discloses a synthesis method of an alpha-keto amide compound, which comprises the following steps: mixing a benzoyl azide compound as shown in a chemical formula I with a benzoyl formicacid compound as shown in a chemical formula II, and reacting to obtain an alpha-keto amide compound as shown in a chemical formula III; in the formula, R1 is a monosubstituted or polysubstituted group on a benzene ring; R2 is a group that is not H; the synthesis method can be used for efficiently synthesizing the functionalized alpha-ketoamide compound, has the advantages of simple synthesis steps, safety in operation, good compatibility of the synthesis method to functional groups and high atom economy, and is easy for industrial synthesis.

Superacid-promoted reactions of α-ketoamides and related systems

(Chemical Equation Presented) The superacid-promoted reactions of α-hydroxy and α-ketoamides have been studied. Ionization of these compounds leads to varied aryl-substituted oxyindole products. In some cases, electrocyclization can lead to substituted fl

Syntheses of Dialkyl and Functionalized Ketones via 1-(Benzotriazol-1-yl)alkyl Methyl Thioethers

Benzotriazol-1-ylmethyl methyl thioether (1), after easy deprotonation by BuLi, reacted with alkyl halides to afford 1-(benzotriazol-1-yl)alkyl methyl thioethers 2 in good yields. The utility of compounds 2 as alkanoyl anion equivalents was demonstrated by the reactions of their anions with alkyl halides, aldehydes, ketones, esters, and phenyl isocyanate: the products were readily hydrolyzed to α-functionalized ketones in dilute aqueous acid.

Substituted (Carbazol-9-yl)(benzotriazol-1-yl)methanes: Novel Acyl Anion Equivalents

Alkyl(carbazol-9-yl)(benzotriazol-1-yl)methanes are deprotonated by BuLi to form anions which react with alkyl halides, aldehydes, and isocyanates to afford the expected products and which add 1,4 to α,β-unsaturated ketones.These products are hydrolyzed by dilute acid at ambient temperature to afford the corresponding ketones.