6362-76-1Relevant academic research and scientific papers
Phase Transfer Catalysed Double Carbonylation of Styrene Oxides
Alper, Howard,Arzoumanian, Henri,Petrignani, Jean-Francois,Saldana-Maldonado, Manuel
, p. 340 - 341 (1985)
A novel double carbonylation of styrene oxides occurs on treatment of the heterocycle with carbon monoxide, methyl iodide, NaOH (0.5 M), C6H6, Co2(CO)8 as the metal catalyst, and cetyltrimethylammonium bromide as the phase transfer agent.
Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation of β-Substituted α-Oxobutyrolactones
Hu, Zi-Qi,Li, Xiang,Liu, Li-Xia,Yu, Chang-Bin,Zhou, Yong-Gui
supporting information, p. 17453 - 17461 (2021/11/18)
A concise and effective ruthenium-catalyzed asymmetric transfer hydrogenation of β-substituted α-oxobutyrolactones has been developed, delivering a series of cis-β-substituted α-hydroxybutyrolactone derivatives with excellent yields, enantioselectivities,
Ni(ii)-Catalyzed vinylic C-H functionalization of 2-acetamido-3-arylacrylates to access isotetronic acids
Das, Eshani,Mal, Dipakranjan,Roy, Avijit,Roy, Biswajit
, p. 3697 - 3706 (2020/06/03)
A ligand-free Ni(ii)-catalyzed cascade annulation reaction for the synthesis of 4-aryl-substituted isotetronic acids from 2-acetamido-3-arylacrylatesviavinylic C-H functionalization is reported. The reaction proceeds through heteroatom guided electrophilic insertion of nickel to the vinylic double bond followed by annulation with dibromomethane. This unconventional route features cascade steps, sole product formation, multiple functional group tolerance, low cost of catalysts and reagents, and readily available starting materials. Using this method, various aryl-substituted isotetronic acids have been synthesized which are biologically relevant. The annulation of 2-acetamido-3-arylacrylates has also been assessed with 1,2-dichloroethane, which resulted in the rearranged annulated products of 5-methyl substituted isotetronic acids.
Synthesis of Cyclic 3-Aryl-Substituted 1,2-Dicarbonyl Compounds via Suzuki Cross-Coupling Reactions
Lopu?anskaja, Eleana,Paju, Anne,J?rving, Ivar,Lopp, Margus
, p. 1883 - 1890 (2018/02/19)
A method for the synthesis of cyclic 3-aryl and heteroaryl-substituted 1,2-dicarbonyl compounds with different ring sizes by using a Suzuki cross-coupling reaction between 3-halo-1,2-dicarbonyl compounds and arylboronic acids is developed. The 3-halo-1,2-dicarbonyl substrates are easily available from 1,2-dicarbonyl compounds. The method is versatile, affording good to high yields of the target compounds.
A catalytic C-C bond-formation with minimal use of protecting groups: Construction of functionalized isotetronic acid derivatives
Shimizu, Yohei,Yasuda, Kouji,Kanai, Motomu
, p. 919 - 927 (2014/01/17)
A catalytic method to construct multi-functionalized isotetronic acids was developed using cyclic hemiacetals and pyruvic acid derivatives as substrates. The key to success was the combination of catalytic amounts of iron(III) trifluoroacetate and 2-mercaptopyridine. A catalytic asymmetric variant was also developed using 6,6'-dimethoxy-binaphthyl phosphate instead of 2-mercaptopyridine.
SYNTHESIS OF UNSATURATED HYDROXY ACIDS BY THE COBALT CARBONYL AND PHASE TRANSFER CATALYZED CARBONYLATION OF VINYL EPOXIDES
Alper, Howard,Calet, Serge
, p. 1763 - 1766 (2007/10/02)
Phase transfer catalyzed reaction of vinyl epoxides with carbon monoxide, methyl iodide, catalytic amounts of cobalt carbonyl and TDA-1, affords β-hydroxy acids.High regioselectivity was observed in some cases.
