63633-75-0Relevant articles and documents
Palladium-catalyzed Sonogashira coupling of amides: Access to ynones: Via C-N bond cleavage
Cui, Ming,Wu, Hongxiang,Jian, Junsheng,Wang, Hui,Liu, Chao,Daniel, Stelck,Zeng, Zhuo
, p. 12076 - 12079 (2016)
The first palladium-catalyzed Sonogashira coupling of amides has been developed, which proceeds via a selective cleavage of the N-acylsaccharin C-N bond. Notably, the new approach employs N-acylsaccharins as coupling partners to give ynones in good to excellent yield. This protocol can be efficiently utilized in the synthesis of a broad array of ynones under low catalyst loading and Cu-free conditions.
Palladium-catalyzed decarbonylative suzuki-miyaura coupling of amides to achieve biaryls via C-N bond cleavage
Luo, Zhongfeng,Xiong, Li,Liu, Tingting,Zhang, Yuqi,Lu, Siqi,Chen, Yuwen,Guo, Weijie,Zhu, Yulin,Zeng, Zhuo
, p. 10559 - 10568 (2019/09/30)
The palladium-catalyzed decarbonylative Suzuki-Miyaura coupling of amides via selective amide C-N bond cleavage was reported, which afforded mild access to substitute biaryl products in the presence of low catalyst loading with NaHCO3 as the base in good yields within 4 h (29 examples).
Suzuki Coupling of Amides via Palladium-Catalyzed C–N Cleavage of N-Acylsaccharins
Wu, Hongxiang,Li, Yue,Cui, Ming,Jian, Junsheng,Zeng, Zhuo
supporting information, p. 3876 - 3880 (2016/12/16)
A palladium-catalyzed cross-coupling of activated amides with arylboronic acids has been developed via C–N bond cleavage. This approach demonstrated high tolerance to a variety of alkyl, aryl, heterocyclic and vinyl substituents. Unsymmetrical ketones could be achieved in excellent yield under mild conditions with 1% catalyst loadings. (Figure presented.).
