636601-27-9

Basic information

• Product Name: 4,4'-Dibromo-1,1'-spirobiindane-7,7'-diol
• Synonyms: 4,4'-Dibromo-1,1'-spirobiindane-7,7'-diol;4,4'-DibroMo-1,1'-spirobiindane-7,7'-diole;1,1'-Spirobi[1H-indene]-7,7'-diol,4,4'-dibromo-2,2',3,3'-tetrahydro-, (1S)- (9CI);(1S)-4,4'-dibromo-2,2',3,3'-tetrahydro-1,1'-Spirobi[1H-indene]-7,7'-diol;(S)-4,4'-Dibromo-1,1'-spirobiindane-7,7'-diol
• CAS NO: 636601-27-9
• Molecular Formula: C17H14 Br2 O2
• Molecular Weight: 410.1
• Mol File: 636601-27-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 161 °C
• Appearance: /
• CAS DataBase Reference: 4,4'-Dibromo-1,1'-spirobiindane-7,7'-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4'-Dibromo-1,1'-spirobiindane-7,7'-diol(636601-27-9)
• EPA Substance Registry System: 4,4'-Dibromo-1,1'-spirobiindane-7,7'-diol(636601-27-9)

Safety Data

• Hazardous Substances Data: 636601-27-9(Hazardous Substances Data)

Usage

General Description

4,4'-Dibromo-1,1'-spirobiindane-7,7'-diol is a chemical compound with the molecular formula C20H16Br2O2. It is a brominated spirobiindane derivative with two bromine atoms attached to the benzene rings. 4,4'-Dibromo-1,1'-spirobiindane-7,7'-diol is used in various applications such as organic synthesis and as a building block for the preparation of pharmaceuticals and agrochemicals. It is also used as a stabilizer in polymers and plastics. Additionally, it has potential pharmacological properties and is being studied for its potential use in the treatment of various diseases. However, it is important to handle this chemical with caution and follow proper safety protocols due to its potential hazards.

Upstream product

• 1427054-10-1 1,5-bis(2-bromo-5-hydroxyphenyl)pentan-3-one 
• 223137-76-6 4,4'-dibromo-7,7'-dimethoxy-1,1'-spirobiindane 
• 100-83-4 meta-hydroxybenzaldehyde 
• 881915-97-5 (1E,4E)-1,5-bis(3-hydroxyphenyl)penta-1,4-dien-3-one 
• 223137-81-3 (S)-7,7'-dimethoxy-2,2',3,3'-tetrahydro-1,1'-spirobi[indene] 
• 636601-27-9 4,4'-dibromo-2,2',3,3'-tetrahydro-1,1'-spirobi[1H-indene]-7,7'-diol 
• 223137-76-6 (S)-4,4'-dibromo-7,7'-dimethoxy-1,1'-spirobiindane 

Downstream Products

• 636601-27-9 (S)-4,4'-dibromo-2,2',3,3'-tetrahydro-1,1'-spirobi[indene]-7,7'-diol 
• 223137-87-9 2,2′,3,3′-tetrahydro-1,1′-spirobi[indene]-7,7′-diol 
• 636601-30-4 (S)-4,4'-dimethoxy-7,7'-dihydroxy-1,1'-spirobiindane 

Relevant articles and documents

SPHENOL, A New Chiral Framework for Asymmetric Synthesis

Privileged chiral catalysts have found tremendous applications and thus immensely advanced asymmetric synthesis in the past few decades. However, truly privileged chiral frameworks are still extremely limited. Thus, the search for and development of new v

COMPOUND AND METHOD FOR PREPARING CHIRAL COMPOUND

A compound and a method for preparing achiral compound using the compound are provided. The compound has a structure of Formula (I) , wherein R1 are independently C1-4 alkyl group or a monovalent group derived from a chiral alcohol a

A convenient resolution method for 1,1′-bi-2-naphthol and 4,4′-dibromo-1,1′-spirobiindane-7,7′-diol with menthyl chloroformate in the presence of TBAB

A convenient resolution method for 1,1′-bi-2-naphthol and 4,4′-dibromo-1,1′-spirobiindane-7,7′-diol has been developed with crude (-)-menthyl chloroformate as the resolution reagent in the presence of tetrabutylammonium bromide acting as a phase transfer catalyst in an aqueous NaOH/CH2Cl2 two phase solution. The deprotection of the hydroxy group was carried out via an aqueous KOH/EtOH solution. Both enantiomers of 1,1′-bi-2-naphthol and 4,4′-dibromo-1,1′- spirobiindane-7,7′-diol were obtained in high yields. Both ee's of (S)-(+) and (R)-(-)-4,4′-dibromo-1,1′-spirobiindane-7,7′-diol were above 99%. Most of the (-)-menthol could be easily recovered in a deprotection procedure and thus be reused for the formation of (-)-menthyl chloroformate without further purification.