63665-87-2 Usage
Uses
Used in Organic Synthesis:
7-METHYLINDAN-4-YL 1-NAPHTHYL KETONE is used as a key intermediate in the synthesis of various organic compounds for [application reason]. Its ability to participate in a range of chemical reactions, such as condensation, oxidation, and reduction, makes it a versatile building block for creating complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 7-METHYLINDAN-4-YL 1-NAPHTHYL KETONE is used as a precursor in the development of new drugs for [application reason]. Its structural features can be exploited to design molecules with specific biological activities, potentially leading to the creation of novel therapeutic agents.
Used in Chemical Research:
7-METHYLINDAN-4-YL 1-NAPHTHYL KETONE is also utilized in chemical research as a model compound for studying reaction mechanisms and exploring new synthetic methodologies for [application reason]. Its reactivity and stability under various conditions provide valuable insights into the behavior of similar compounds and contribute to the advancement of organic chemistry.
Used in Material Science:
7-METHYLINDAN-4-YL 1-NAPHTHYL KETONE finds applications in material science, where it is used as a component in the development of new materials with unique properties for [application reason]. Its incorporation into polymers, for instance, can lead to materials with improved thermal stability, mechanical strength, or other desirable characteristics.
Synthesis Reference(s)
The Journal of Organic Chemistry, 46, p. 3429, 1981 DOI: 10.1021/jo00330a008
Check Digit Verification of cas no
The CAS Registry Mumber 63665-87-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,6,6 and 5 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 63665-87:
(7*6)+(6*3)+(5*6)+(4*6)+(3*5)+(2*8)+(1*7)=152
152 % 10 = 2
So 63665-87-2 is a valid CAS Registry Number.
InChI:InChI=1/C21H18O/c1-14-12-13-20(18-10-5-9-16(14)18)21(22)19-11-4-7-15-6-2-3-8-17(15)19/h2-4,6-8,11-13H,5,9-10H2,1H3
63665-87-2Relevant academic research and scientific papers
Improved Synthesis of 3-Methylcholanthrene
Tang, Ping Wah,Maggiulli, Cataldo A.
, p. 3429 - 3432 (2007/10/02)
An improved synthesis of 7-methylindan-4-yl 1-naphthyl ketone (3), an important precursor of 3-methylcholanthrene (1), has been developed.The key intermediates for 3, 4-cyano-7-methylindan (2a) and 4-(ethoxycarbonyl)-7-methylindan (2b), were conveniently prepared in high yields by reaction of 1-(1-pyrrolidino)cyclopentene (6) with sorbonitrile (5a) or ethyl sorbate (5b), followed by aromatization with sulfur. 1-Naphthylmagnesium bromide (4b) in the presence of cuprous iodide reacted cleanly with 4-(chloromethanoyl)-7-methylindan (12) to give 3.The Friedel-Crafts acylation of naphthalene with 12 afforded 84percent of 3 and 16percent of β isomer 13.Alternatively, 3 was prepared in 75percent yield by condensation of Grignard reagent 4b with 2a in THF.Thermal annelation of 3 afforded 1 in 41.5percent yield.
