6367-42-6

Usage

Uses

Used in Scientific Research:
H-D-ASP-OBZL is used as a research tool for studying the endocannabinoid system and the role of FAAH in regulating endocannabinoid signaling. By inhibiting FAAH, it can increase the levels of endogenous cannabinoids, such as anandamide, which may lead to potential therapeutic effects for various conditions.
Used in Pharmaceutical Development:
H-D-ASP-OBZL is used as a lead compound in the development of new treatments targeting FAAH. Its ability to increase endogenous cannabinoid levels suggests potential therapeutic effects for conditions such as pain, inflammation, and anxiety, making it a promising candidate for the development of novel pharmaceuticals.
Used in Drug Discovery:
H-D-ASP-OBZL is used as a starting point for drug discovery efforts focused on the endocannabinoid system. Its unique structure and high potency provide a foundation for the design and synthesis of new compounds with improved pharmacological properties and therapeutic potential.
Used in Neurological Research:
H-D-ASP-OBZL is used in neurological research to investigate the role of the endocannabinoid system in various neurological disorders and conditions. Its ability to modulate endocannabinoid signaling may provide insights into the development of new treatments for neurological conditions such as epilepsy, multiple sclerosis, and neurodegenerative diseases.
Used in Pain Management Research:
H-D-ASP-OBZL is used in pain management research to explore the potential of the endocannabinoid system in the treatment of chronic and acute pain. Its ability to increase endogenous cannabinoid levels may offer a novel approach to pain relief and the management of pain-related conditions.

InChI:InChI=1/C11H13NO4/c13-10(14)6-9(11(15)16)12-7-8-4-2-1-3-5-8/h1-5,9,12H,6-7H2,(H,13,14)(H,15,16)/t9-/m1/s1

Upstream product

• 1783-96-6 (2R)-aspartic acid 
• 100-52-7 benzaldehyde 
• 84028-93-3 (R)-Benzylasparaginsaeure-diethylester 

Relevant academic research and scientific papers

Engineered C–N Lyase: Enantioselective Synthesis of Chiral Synthons for Artificial Dipeptide Sweeteners

Aspartic acid derivatives with branched N-alkyl or N-arylalkyl substituents are valuable precursors to artificial dipeptide sweeteners such as neotame and advantame. The development of a biocatalyst to synthesize these compounds in a single asymmetric step is an as yet unmet challenge. Reported here is an enantioselective biocatalytic synthesis of various difficult N-substituted aspartic acids, including N-(3,3-dimethylbutyl)-l-aspartic acid and N-[3-(3-hydroxy-4-methoxyphenyl)propyl]-l-aspartic acid, precursors to neotame and advantame, respectively, using an engineered variant of ethylenediamine-N,N′-disuccinic acid (EDDS) lyase from Chelativorans sp. BNC1. This engineered C–N lyase (mutant D290M/Y320M) displayed a remarkable 1140-fold increase in activity for the selective hydroamination of fumarate compared to that of the wild-type enzyme. These results present new opportunities to develop practical multienzymatic processes for the more sustainable and step-economic synthesis of an important class of food additives.

Total Synthesis of Microcystin-LF and Derivatives Thereof

Microcystins (MCs) are highly toxic natural products which are produced by cyanobacteria. They can be released to the water during harmful algal blooms and are a serious threat to animals and humans. Described is the total synthesis of the cyanotoxin micr

Amino Acids, 4 - Enantioselective Synthesis of N-Substituted α-Amino Carboxylic Acids from α-Hydroxy Carboxylic Acids

With primary and secondary amines, the (S)-α-(trifluoromethylsulfonyloxy) carboxylates (S)-3 afford in an SN2 reaction the N-substituted (R)-α-amino carboxylates (R)-5, (R)-9, and (R)-12, resp.The rates of α-substituted ethyl propionates decrease in the order of the substituents triflate (3a) >> bromide (8a) > mesylate (7a) >= tosylate (7b) > chloride (8b); in the reactions with amines, decreasing reactivity affords increasing racemisation and elimination as a consequence of the more drastic conditions which are required