Bioorganic and Medicinal Chemistry Letters p. 1081 - 1086 (1999)
Update date:2022-08-29
Topics:
Pinney, Kevin G.
Bounds, A. Dawn
Dingeman, Koren M.
Mocharla, Vani P.
Pettit, George R.
Bai, Ruoli
Hamel, Ernest
A new type of inhibitor of tubulin polymerization was discovered based on the 3-aroyl-2-arylbenzo[b]thiophene molecular skeleton. The lead compound in this series, 2-(4'-methoxyphenyl)-3-(3',4',5'-trimethoxybenzoyl)-6- methoxybenzo[b]thiophene 1, inhibited tubulin polymerization, caused an increase in the mitotic index of CA46 Burkitt lymphoma cells, and inhibited the growth of several human cancer cell lines.
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Doi:10.1021/jacs.5b13211
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(1952)Doi:10.1002/(SICI)1099-1344(1998110)41:11<977::AID-JLCR143>3.0.CO;2-J
(1998)Doi:10.1039/c6ra11460a
(2016)Doi:10.1021/jo0710634
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