63693-65-2

Basic information

• Product Name: 1-(4-ISOPROPYLPHENYL)HYDRAZINE
• Synonyms: 1-(4-ISOPROPYLPHENYL)HYDRAZINE;(4-ISOPROPYL-PHENYL)-HYDRAZINE;Hydrazine, [4-(1-methylethyl)phenyl]- (9CI);1-(4-Isopropylphenyl)hydrazine, 90+%;Hydrazine, [4-(1-Methylethyl)phenyl]-;N-(4-Isopropylphenyl)hydrazine
• CAS NO: 63693-65-2
• Molecular Formula: C₉H₁₄N₂
• Molecular Weight: 150.22
• Product Categories: ISOPROPYL
• Mol File: 63693-65-2.mol

Chemical Properties

• Melting Point: 66-69°C
• Boiling Point: 260.1 °C at 760 mmHg
• Flash Point: 128.1 °C
• Appearance: /
• Density: 1.027 g/cm³
• PKA: 5.39±0.20(Predicted)
• CAS DataBase Reference: 1-(4-ISOPROPYLPHENYL)HYDRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-ISOPROPYLPHENYL)HYDRAZINE(63693-65-2)
• EPA Substance Registry System: 1-(4-ISOPROPYLPHENYL)HYDRAZINE(63693-65-2)

Safety Data

• Statements: 20/21/22
• Safety Statements: 22-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 63693-65-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-Isopropylphenyl)hydrazine is used as a synthetic intermediate for the development of various drugs and organic compounds. Its ability to form hydrazones and other nitrogen-containing compounds contributes to the creation of novel pharmaceutical agents with potential therapeutic applications.
Used in Chemical Industry:
In the chemical industry, 1-(4-Isopropylphenyl)hydrazine is utilized as a reagent in the synthesis of a wide range of organic compounds. Its versatility in forming different nitrogen-containing compounds makes it an essential component in the development of new materials and chemical processes.
Used in Medicinal Chemistry:
1-(4-Isopropylphenyl)hydrazine has potential applications in medicinal chemistry, where it can be employed to design and synthesize new pharmaceutical agents with improved therapeutic properties. Its ability to form hydrazones and other nitrogen-containing compounds can be leveraged to create innovative drug candidates with enhanced efficacy and selectivity.
Overall, 1-(4-IsoPropylphenyl)HYDRAZINE is a crucial chemical compound with diverse applications in the pharmaceutical, chemical, and medicinal chemistry industries, primarily due to its unique properties and reactivity in organic synthesis.

InChI:InChI:1S/C9H14N2/c1-7(2)8-3-5-9(11-10)6-4-8/h3-7,11H,10H2,1-2H3

Upstream product

• 99-88-7 4-Isopropylaniline 
• 118427-29-5 (4-isopropylphenyl)hydrazine hydrochloride 

Downstream Products

• 99-88-7 4-Isopropylaniline 
• 890130-35-5 3-tert-butyl-1-[4-(propan-2-yl)phenyl]-1H-pyrazol-5-amine 
• 374924-84-2 5-methyl-2-[4-(2-methylethyl)phenyl]-2,4-dihydropyrazol-3-one 
• 1046451-53-9 4,5-dihydro-6-methyl-2-(p-isopropylphenyl)-3(2H)-pyridazinone 
• 1033725-91-5 1-(4-isopropylphenyl)-3-methyl-4,5-dihydropyrazole 
• 1224734-28-4 2-((2-(4-isopropylphenyl)hydrazinyl)methylene)-1H-indene-1,3(2H)-dione 
• 1246517-81-6 5-(4-fluorophenyl)-1-(4-isopropylphenyl)pyrazolidin-3-one 
• 1246517-80-5 1-(4-isopropylphenyl)-5-phenylpyrazolidin-3-one 
• 1154037-39-4 1-(4-isopropylphenyl)-5-(4-methoxyphenyl)pyrazolidin-3-one 
• 1393580-78-3 (Z)-4-(4-ethoxy-3-methoxybenzylidene)-1-(4-isopropylphenyl)-3-methyl-1H-pyrazol-5(4H)-one 
• 957247-54-0 tert-butyl 4-(4-(ethoxycarbonyl)-1-(4-isopropylphenyl)-1H-pyrazol-5-yl)piperidine-1-carboxylate 

Relevant articles and documents

Lewis Acid Catalyzed Annulation of Cyclopropane Carbaldehydes and Aryl Hydrazines: Construction of Tetrahydropyridazines and Application Toward a One-Pot Synthesis of Hexahydropyrrolo[1,2- b]pyridazines

In this report, a facile synthesis of tetrahydropyridazines via a Lewis acid catalyzed annulation reaction of cyclopropane carbaldehydes and aryl hydrazines has been demonstrated. Moreover, the generated tetrahydropyridazine further participated in a cycloaddition reaction with donor-acceptor cyclopropanes to furnish hexahydropyrrolo[1,2-b]pyridazines. We also performed these two steps in one pot in a consecutive manner. In addition, a monodecarboxylation reaction of hexahydropyrrolo[1,2-b]pyridazine was achieved with a good yield.

Synthesis of benzofuro[3,2-b] indoline amines via deamination-interrupted Fischer indolization and their unexpected reactivity towards nucleophiles

We report the access to the benzofuro[3,2-b]indoline framework of phalarine from benzofuran-2-ones via the Fischer indolization reaction which was interrupted at the deamination step. Unexpectedly, allyl nucleophiles did not add to the aminal position of these benzofuro[3,2-b]indoline amines but to the adjacent ring junction center in the presence of trifluoroborane to deliver 3,3-disubstituted indolines containing a difluoroboron-containing six-membered ring with fluorescence properties.

Synthesis, crystal structure, and fungicidal activity of novel 1,5-Diaryl-1H-pyrazol-3-oxyacetate derivatives

A series of ethyl 2-(1,5-diaryl-1H-pyrazol-3-yloxy)acetate derivatives (5a-5i) have been efficiently synthesized by the reaction of 1,5-diaryl-1H-pyrazol-3-ols (4a-4i) with ethyl 2-bromoacetate. The structures of the newly synthesized compounds were characterized by 1H NMR spectra and elemental analysis, and the crystal structure of the compound ethyl 2-(5-(4-chlorophenyl)-1-phenyl-1H-pyrazol-3-yloxy)acetate (5c) was determined by single crystal X-ray diffraction analysis. The compound 5c belongs to triclinic system with space group P(-1), a = 5.8170(12) A, b = 11.804(2) A, c = 12.783(2) A, α = 83.89(2)°, β = 89.24(3)°, γ = 89.73(3)°, Formula weight: 356.80, Triclinic V = 872.7(3) A3, Dc = 1.358 mg/m3, Z = 2, F (000) = 372. Bioassay results indicated that the compound ethyl 2-(5-(4-fluorophenyl)-1- phenyl-1H-pyrazol-3-yloxy)acetate (5d) exhibited moderate inhibitory activity against Gibberella zeae at the dosage of 10 μg/mL.