957247-54-0

Basic information

• Product Name: tert-butyl 4-(4-(ethoxycarbonyl)-1-(4-isopropylphenyl)-1H-pyrazol-5-yl)piperidine-1-carboxylate
• Synonyms: tert-butyl 4-(4-(ethoxycarbonyl)-1-(4-isopropylphenyl)-1H-pyrazol-5-yl)piperidine-1-carboxylate
• CAS NO: 957247-54-0
• Molecular Weight: 441.571
• Mol File: 957247-54-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-(4-(ethoxycarbonyl)-1-(4-isopropylphenyl)-1H-pyrazol-5-yl)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(4-(ethoxycarbonyl)-1-(4-isopropylphenyl)-1H-pyrazol-5-yl)piperidine-1-carboxylate(957247-54-0)
• EPA Substance Registry System: tert-butyl 4-(4-(ethoxycarbonyl)-1-(4-isopropylphenyl)-1H-pyrazol-5-yl)piperidine-1-carboxylate(957247-54-0)

Safety Data

• Hazardous Substances Data: 957247-54-0(Hazardous Substances Data)

Upstream product

• 498-94-2 isonipecotic acid 
• 1336874-02-2 tert‐butyl 4‐(2,2‐dimethyl‐4,6‐dioxo‐1,3‐dioxane‐5‐carbonyl)piperidine‐1‐carboxylate 
• 1336874-05-5 (E,Z)-tert-butyl-4-(3-ethoxy-2-(ethoxycarbonyl)acryloyl)piperidine-1-carboxylate 
• 118427-29-5 (4-isopropylphenyl)hydrazine hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 479630-08-5 4-(2-ethoxycarbonylacetyl)piperidine-1-carboxylic acid tert-butyl ester 
• 63693-65-2 4-isopropylphenylhydrazine 

Downstream Products

• 1020196-55-7 N-(3,5-dimethylphenyl)-1-(4-isopropylphenyl)-5-(piperidin-4-yl)-1H-pyrazole-4-carboxamide 
• 1020050-02-5 5-(1-(tert-butoxycarbonyl)piperidin-4-yl)-1-(4-isopropylphenyl)-1H-pyrazole-4-carboxylic acid 
• 1020050-10-5 tert-butyl 4-(4-((3,5-dimethylphenyl)carbamoyl)-1-(4-isopropylphenyl)-1H-pyrazol-5-yl)piperidine-1-carboxylate 

Relevant articles and documents

Compounds and methods for treating cancer by inhibiting the urokinase receptor

Compounds and methods for treating or preventing cancer associated with binding to the urokinase receptor are provided. Biological processes affected by the compounds include cell migration, cell growth, cell adhesion, angiogenesis, cancer cell invasion, apoptosis, tumor formation, tumor progression, metastasis, degradation of the extracellular matrix, pericellular proteolysis, activation of plasminogen, changes in the levels of an extracellular protease, and changes in the levels of a VEGF receptor.

Virtual screening targeting the urokinase receptor, biochemical and cell-based studies, synthesis, pharmacokinetic characterization, and effect on breast tumor metastasis

Virtual screening targeting the urokinase receptor (uPAR) led to (±)-3-(benzo[d][1,3]dioxol-5-yl)-N-(benzo[d][1,3]dioxol-5-ylmethyl) -4-phenylbutan-1-amine 1 (IPR-1) and N-(3,5-dimethylphenyl)-1-(4- isopropylphenyl)-5-(piperidin-4-yl)-1H-pyrazole-4-carbox