637-19-4Relevant academic research and scientific papers
An Environment-friendly Synthesis of 2,3-Disubstituted-2-iminothiazoline-4-ones
Meng, Ge,Zheng, Meilin,Dong, Mengshu,Wang, Mei,Zheng, Aqun,Guo, Zengjun
, p. 588 - 594 (2016/04/19)
A series of 2,3-substituted-2-iminothiazoline-4-ones derivatives have been synthesized via an improved method including an auto-catalyzed reaction. This method avoided using any extra catalyst except for the reaction material. This method has been successful in both the aromatic substituted 2-iminothiazolines and the alkyl substituted 2-iminothiazolines. The special product with a hydroxyl group on the 2-iminogroup of 1,3-thiazoline-4-ones has also been obtained unexpectedly. The possible mechanism has been proposed for the special process of dealkylation and hydroxylation. This method offered a special way to afford the 2-hydroxyimino-substituted thiazoline-4-one derivatives in an efficient and eco-friendly way. The mechanism of the transformation under acid condition has also been proposed.
New potent imidazoisoquinolinone derivatives as anti-Trypanosoma cruzi agents: Biological evaluation and structure-activity relationships
Bollini, Mariela,Casal, Juan Jose,Alvarez, Diego E.,Boiani, Lucia,Gonzalez, Mercedes,Cerecetto, Hugo,Bruno, Ana Maria
experimental part, p. 1437 - 1444 (2009/09/25)
A series of novel benzoimidazo and N-aryl-5-oxo-imidazo[1,2-b]isoquinoline-10-carbothioamides was developed. All the compounds were evaluated for their in vitro action against the epimastigote form of Trypanosoma cruzi. Four of them showed higher activity than Nifurtimox. Their unspecific cytotoxicity was evaluated using HeLa and L6 cells, being non-toxic at concentrations at least 15 and 200 times higher than that of T. cruzi IC50. To gain insight into the mechanism of action, their DNA binding properties and reactivity with glutathione were studied, and QSAR study was performed.
