637337-65-6

Usage

Uses

Used in Pharmaceutical and Biotechnology Research:
Cbz-S-3-Aminoisobutyric acid is used as a key building block for the synthesis of peptidomimetics and bioactive peptides. Its carboxybenzyl protecting group allows for controlled reactivity of the amine during peptide bond formation, which is crucial for the development of novel therapeutic agents and bioactive compounds.
Used in Peptide Synthesis:
Cbz-S-3-Aminoisobutyric acid is used as a component in peptide synthesis for its ability to control the reactivity of the amine group. This feature is essential in the formation of peptide bonds, ensuring the accurate and efficient synthesis of desired peptide sequences.
Used in the Development of Novel Therapeutic Agents:
As a building block in the synthesis of bioactive peptides, Cbz-S-3-Aminoisobutyric acid contributes to the development of new therapeutic agents with potential applications in various medical fields. Its role in the controlled synthesis of peptides allows for the creation of compounds with specific biological activities and therapeutic properties.

Upstream product

• 92932-15-5 2-(2'-cyanopropyl)-1H-isoindole-1,3(2H)-dione 
• 28267-25-6 (RS)-2-(aminomethyl)propanoic acid hydrochloride 
• 501-53-1 benzyl chloroformate 
• 10569-72-9 DL-3-aminoisobutyric acid 
• 94471-35-9 benzyl N-(methoxymethyl) carbamate 
• 117903-81-8 2-(2'-cyanoprop-2'-enyl)-1H-isoindole-1,3(2H)-dione 
• 67799-90-0 diethyl 2-(N-methylphthalimido)-2-methylmalonate 

Relevant academic research and scientific papers

Enantioselective preparation of 2-aminomethyl carboxylic acid derivatives: Solving the β2-amino acid problem with the chiral auxiliary 4-isopropyl-5,5-diphenyloxazolidin-2-one (DIOZ)

Multigram amounts of suitably protected β2-amino acids with 17 of the 20 proteinogenic side chains are prepared by diastereoselective reactions of Li, B, or Ti enolates of the corresponding 3-acyl-4-isopropyl-5,5-diphenyloxazolidin-2-ones (acyl-DIOZ; 1) with appropriate electrophiles (amidomethylation, hydroxyalkylation, (benzyloxycarbonyl)methylation) in yields of 55-90% and with diastereoselectivities of 80 to > 97% (Scheme). The primary products 2-8 thus obtained are converted to protected β2-amino acids by standard procedures (Table 1). Many of the DIOZ derivatives are highly crystalline compounds (31 X-ray crystal structures in Table 2). The chiral auxiliary DIOZ, readily prepared in either enantiomeric form, is recovered with high yield.

Synthesis and conformational analysis of 1,3,2-diazaphosphorino[6,1-a] isoquinolines, a new ring system

Through ring-closure reactions of N- or 1′-substituted 1-(2′-aminoethyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines (5a-e) with phenylphosphonyl dichloride, 1- or 3-substituted 4-phenyl-1,3,4,6,7,11b- tetrahydro-2H-1,3,2-diazaphosphorino[6,1-a]isoquinolin-4-one diastereomers (7a-e and 8a-c,e), the first representatives of a new ring system, were prepared. The diastereomeric ratios in the cyclizations and the conformer (A-E) populations of the nitrogen-bridged tricyclic systems (7 and 8) were strongly influenced by the N- and 1′-substituents of the starting diamines. The conformational analysis of compounds 7 and 8 was performed by 1H, 13C and 31P NMR methods.

METHODS OF TREATING ALZHEIMER'S DISEASE USING ARYL ALKANOIC ACID AMIDES

Disclosed are methods for treating Alzheimer’s disease, and other diseases, and/or inhibiting beta-secretase enzyme, and/or inhibiting deposition of A beta peptide in a mammal, by use of compounds of formula 1 (1) wherein the variables R1-R8 and X are defined herein.

Chartreusin derivatives and salts thereof

This invention relates to a novel chartreusin derivative of the general formula (I): STR1 and a salt thereof. This chartreusin derivative and a salt thereof have an excellent antitumor activity, which is exhibited even when the site of cancer inoculation and the site of drug administration are different. This invention further relates to a antitumorous composition containing the above-mentioned compound as active ingredient. This invention furthermore relates to a process for producing the above-mentioned chartreusin derivative or salt thereof.

THE HYDROCYANATION ROUTE TO β- AND γ-AMINO ACIDS. A SYNTHESIS OF α-METHYLENE-β-ALANINE

Hydrocyanation of several phthalimidoalkynes proceeds with good regioselection yielding products which were easily converted into unsaturated β- and γ-amino acids.

Chartreusin derivatives and salts thereof

This invention relates to a novel chartreusin derivative of the general formula (I): STR1 and a salt thereof. This chartreusin derivative and a salt thereof have an excellent antitumor activity, which is exhibited even when the site of cancer inoculation