637337-65-6

Basic information

• Product Name: Cbz-S-3-Aminoisobutyric acid
• Synonyms: Cbz-S-3-Aminoisobutyric acid;(S)-3-(benzyloxycarbonylamino)-2-methylpropanoic acid;REF DUPL: Cbz-S-3-Aminoisobutyric acid;Cbz-(S)-3-Amino-2-methylpropanoic acid
• CAS NO: 637337-65-6
• Molecular Formula: C12H15NO4
• Molecular Weight: 237.2518
• Mol File: 637337-65-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 435.6±38.0 °C(Predicted)
• Appearance: /
• Density: 1.213±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 4.52±0.10(Predicted)
• CAS DataBase Reference: Cbz-S-3-Aminoisobutyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: Cbz-S-3-Aminoisobutyric acid(637337-65-6)
• EPA Substance Registry System: Cbz-S-3-Aminoisobutyric acid(637337-65-6)

Safety Data

• Hazardous Substances Data: 637337-65-6(Hazardous Substances Data)

Usage

General Description

Cbz-S-3-Aminoisobutyric acid is a derivative of the amino acid alanine and is commonly used in peptide synthesis. It is a white solid with a molecular weight of 275.3 g/mol and a chemical formula of C12H17N3O4. The compound contains a carboxybenzyl (Cbz) protecting group on the amino group, which makes it useful for controlling the reactivity of the amine during peptide bond formation. Cbz-S-3-Aminoisobutyric acid is a key building block in the synthesis of peptidomimetics and bioactive peptides, making it an important chemical in pharmaceutical and biotechnology research.

Upstream product

• 28267-25-6 (RS)-2-(aminomethyl)propanoic acid hydrochloride 
• 501-53-1 benzyl chloroformate 
• 94471-35-9 benzyl N-(methoxymethyl) carbamate 
• 10569-72-9 DL-3-aminoisobutyric acid 
• 117903-81-8 2-(2'-cyanoprop-2'-enyl)-1H-isoindole-1,3(2H)-dione 
• 92932-15-5 2-(2'-cyanopropyl)-1H-isoindole-1,3(2H)-dione 
• 67799-90-0 diethyl 2-(N-methylphthalimido)-2-methylmalonate 

Relevant articles and documents

Enantioselective preparation of 2-aminomethyl carboxylic acid derivatives: Solving the β2-amino acid problem with the chiral auxiliary 4-isopropyl-5,5-diphenyloxazolidin-2-one (DIOZ)

Multigram amounts of suitably protected β2-amino acids with 17 of the 20 proteinogenic side chains are prepared by diastereoselective reactions of Li, B, or Ti enolates of the corresponding 3-acyl-4-isopropyl-5,5-diphenyloxazolidin-2-ones (acyl-DIOZ; 1) with appropriate electrophiles (amidomethylation, hydroxyalkylation, (benzyloxycarbonyl)methylation) in yields of 55-90% and with diastereoselectivities of 80 to > 97% (Scheme). The primary products 2-8 thus obtained are converted to protected β2-amino acids by standard procedures (Table 1). Many of the DIOZ derivatives are highly crystalline compounds (31 X-ray crystal structures in Table 2). The chiral auxiliary DIOZ, readily prepared in either enantiomeric form, is recovered with high yield.

METHODS OF TREATING ALZHEIMER'S DISEASE USING ARYL ALKANOIC ACID AMIDES

Disclosed are methods for treating Alzheimer’s disease, and other diseases, and/or inhibiting beta-secretase enzyme, and/or inhibiting deposition of A beta peptide in a mammal, by use of compounds of formula 1 (1) wherein the variables R1-R8 and X are defined herein.

Chartreusin derivatives and salts thereof

This invention relates to a novel chartreusin derivative of the general formula (I): STR1 and a salt thereof. This chartreusin derivative and a salt thereof have an excellent antitumor activity, which is exhibited even when the site of cancer inoculation and the site of drug administration are different. This invention further relates to a antitumorous composition containing the above-mentioned compound as active ingredient. This invention furthermore relates to a process for producing the above-mentioned chartreusin derivative or salt thereof.