63744-24-1Relevant academic research and scientific papers
Synthesis, in vitro anticancer activity and SAR studies of arylated imidazo[1,2-a]pyrazine-coumarin hybrids
Goel, Richa,Luxami, Vijay,Paul, Kamaldeep
, p. 37887 - 37895 (2015/05/20)
A new series of imidazo[1,2-a]pyrazine-coumarin hybrids have been synthesized by the combination of two biologically active moieties, imidazo[1,2-a]pyrazine and coumarin, followed by the Suzuki-Miyaura cross coupling reaction for monoarylation at the C6 p
Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells
Bouloc, Nathalie,Large, Jonathan M.,Kosmopoulou, Magda,Sun, Chongbo,Faisal, Amir,Matteucci, Mizio,Reynisson, Jóhannes,Brown, Nathan,Atrash, Butrus,Blagg, Julian,McDonald, Edward,Linardopoulos, Spiros,Bayliss, Richard,Bavetsias, Vassilios
scheme or table, p. 5988 - 5993 (2010/11/02)
Co-crystallisation of the imidazo[1,2-a]pyrazine derivative 15 (3-chloro-N-(4-morpholinophenyl)-6-(pyridin-3-yl)imidazo[1,2-a]pyrazin-8-amine) with Aurora-A provided an insight into the interactions of this class of compound with Aurora kinases. This led to the design and synthesis of potent Aurora-A inhibitors demonstrating up to 70-fold selectivity in cell-based Aurora kinase pharmacodynamic biomarker assays.
IMIDAZOPYRAZINE COMPOUNDS
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Page/Page column 75, (2009/04/25)
Novel imidazopyrazine compounds are disclosed that have a formula represented by the following: Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a viral infection, in particular a HCV, HRV, Sb and/or CVB in a patient in need thereof.
Novel imidazopyrazines as cyclin dependent kinase inhibitors
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Page/Page column 46, (2008/06/13)
In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyrazine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, me
8-alkylaminoimidazo(1,2-a)pyrazines and derivatives, their preparation and their application in therapy
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, (2008/06/13)
STR1 Novel 8-alkylamino-imidazo(1,2-a)pyrazines of formula (I) show advantages pharmacological activities. They can be used for medical products in human and veterinary therapy in the field of applications of antispasmodics, uterine relaxants, bronchodila
