637744-49-1

Basic information

• Product Name: 3-fluoro-N-(3,4,5-trifluorobenzyl)aniline
• Synonyms: 3-fluoro-N-(3,4,5-trifluorobenzyl)aniline;N-(3,4,5-trifluorobenzyl)-3-fluorobenzenaMine;3-fluoro-N-(3,4,5-trifluorobenzyl)benzenaMine
• CAS NO: 637744-49-1
• Molecular Formula: C₁₃H₉F₄N
• Molecular Weight: 255.2108728
• EINECS: -0
• Mol File: 637744-49-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-fluoro-N-(3,4,5-trifluorobenzyl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-fluoro-N-(3,4,5-trifluorobenzyl)aniline(637744-49-1)
• EPA Substance Registry System: 3-fluoro-N-(3,4,5-trifluorobenzyl)aniline(637744-49-1)

Safety Data

• Hazardous Substances Data: 637744-49-1(Hazardous Substances Data)

Usage

General Description

3-fluoro-N-(3,4,5-trifluorobenzyl)aniline is a chemical compound with the molecular formula C13H8F4N. It is a substituted aniline derivative with a fluorine atom attached to the third carbon of the benzene ring and a trifluoromethyl group attached to the benzyl group. 3-fluoro-N-(3,4,5-trifluorobenzyl)aniline is often used in pharmaceutical and research applications due to its unique structure and properties. It may be used as a building block in the synthesis of other organic compounds or as a reagent in chemical reactions. The presence of fluorine atoms in the molecule can enhance the compound's lipophilicity and thus influence its biological activity. However, due to its potential toxicity and reactive nature, it should be handled and used with caution in a controlled laboratory environment.

Upstream product

• 132123-54-7 3,4,5-trifluorobenzaldehyde 
• 372-19-0 meta-fluoroaniline 
• 1202493-05-7 C₁₃H₇F₄N 
• 220141-72-0 3,4,5-trifluorobenzyl bromide 

Downstream Products

• 637744-48-0 (3-fluorophenyl)(3,4,5-trifluorobenzyl)carbamoyl chloride 
• 385367-47-5 Tarafenacin 
• 637744-70-8 (3R)-3-[(3-fluorophenyl)(3,4,5-trifluorobenzyl)carbamoyloxy]-1-(2-phenoxyethyl)-1-azoniacyclo[2.2.2]octane bromide 

Relevant articles and documents

Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl carbamates as potent and long acting muscarinic antagonists

Novel quaternary ammonium derivatives of N,N-disubstituted (3R)-quinuclidinyl carbamates have been identified as potent M3 muscarinic antagonists with long duration of action in an in vivo model of bronchoconstriction. These compounds have also presented a high level of metabolic transformation (human liver microsomes). The synthesis, structure-activity relationships and biological evaluation of these compounds are reported.

NOVEL QUINUCLIDINE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME

Carbamates of formula (I) or pharmaceutically acceptable salts thereof, including quaternary ammonium salts of formula (II) are disclosed; as well as processes for their preparation, pharmaceutical compositions comprising them and their use in therapy as antagonists of M3 muscarinic receptors.