637744-70-8

Basic information

• Product Name: (3R)-3-[(3-fluorophenyl)(3,4,5-trifluorobenzyl)carbamoyloxy]-1-(2-phenoxyethyl)-1-azoniacyclo[2.2.2]octane bromide
• CAS NO: 637744-70-8
• Molecular Weight: 609.458
• Mol File: 637744-70-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (3R)-3-[(3-fluorophenyl)(3,4,5-trifluorobenzyl)carbamoyloxy]-1-(2-phenoxyethyl)-1-azoniacyclo[2.2.2]octane bromide(CAS DataBase Reference)
• NIST Chemistry Reference: (3R)-3-[(3-fluorophenyl)(3,4,5-trifluorobenzyl)carbamoyloxy]-1-(2-phenoxyethyl)-1-azoniacyclo[2.2.2]octane bromide(637744-70-8)
• EPA Substance Registry System: (3R)-3-[(3-fluorophenyl)(3,4,5-trifluorobenzyl)carbamoyloxy]-1-(2-phenoxyethyl)-1-azoniacyclo[2.2.2]octane bromide(637744-70-8)

Safety Data

• Hazardous Substances Data: 637744-70-8(Hazardous Substances Data)

Upstream product

• 385367-47-5 Tarafenacin 
• 589-10-6 phenoxyethyl bromide 
• 637744-49-1 (3-Fluorophenyl)-(3,4,5-trifluorobenzyl)amine 
• 1202493-05-7 C₁₃H₇F₄N 
• 637744-48-0 (3-fluorophenyl)(3,4,5-trifluorobenzyl)carbamoyl chloride 
• 372-19-0 meta-fluoroaniline 
• 132123-54-7 3,4,5-trifluorobenzaldehyde 

Relevant articles and documents

Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl carbamates as potent and long acting muscarinic antagonists

Novel quaternary ammonium derivatives of N,N-disubstituted (3R)-quinuclidinyl carbamates have been identified as potent M3 muscarinic antagonists with long duration of action in an in vivo model of bronchoconstriction. These compounds have also presented a high level of metabolic transformation (human liver microsomes). The synthesis, structure-activity relationships and biological evaluation of these compounds are reported.