63777-81-1Relevant academic research and scientific papers
Phase-Vanishing Method with Acetylene Evolution and Its Utilization in Several Organic Syntheses
Matake, Ryosuke,Niwa, Yuki,Matsubara, Hiroshi
supporting information, p. 2354 - 2357 (2015/06/02)
A novel quadraphasic phase-vanishing system in which acetylene is evolved from calcium carbide and directly applied in situ to the Sonogashira coupling reaction was developed. This method, which provides a safe, convenient, and one-pot means to utilize gaseous reagents without special equipment, was also applied to a Cu-catalyzed azide-alkyne cycloaddition (CuAAC) reaction and a three-component aldehyde-alkyne-amine (A3) coupling reaction with excellent results. (Figure Presented).
