63777-98-0

Upstream product

• 108-05-4 vinyl acetate 
• 126799-83-5 2-methylbenzylazide 
• 288-36-8 1,2,3-triazole 
• 89-92-9 2-methylbenzyl bromide 
• 75-20-7 calcium carbide 
• 552-45-4 1-chloromethyl-2-methylbenzene 
• 471-25-0 Propiolic acid 
• 74-86-2 acetylene 

Downstream Products

• 1620125-47-4 2-(1-(2-methylbenzyl)-1H-1,2,3-triazol-5-yl)pyridine 1-oxide 

Relevant academic research and scientific papers

Method for synthesizing 1,2,3-triazole derivatives with N1 site being substituted

The invention relates to a method for synthesizing a 1,2,3-triazole derivative with a N1 site being substituted. The method comprises the steps that cuprous oxide is used as a catalyst and N,N'-dimethylethylenediamine is used as a ligand, and the reaction

Self-Assembled Polymeric Pyridine Copper Catalysts for Huisgen Cycloaddition with Alkynes and Acetylene Gas: Application in Synthesis of Tazobactam

Novel convoluted polymeric pyridine copper(I) catalysts PVPy-Cu were developed for the Huisgen cyclization of organic azides using alkynes and acetylene gas. They were readily prepared based on our molecular convolution of CuSO4·5H2O and poly(4-vinylpyridine) (PVPy) in the presence of sodium ascorbate with and without various sodium salts in water. Their structural investigation was conducted using XANES and EXAFS, as well as DFT calculation. The Huisgen cycloaddition of a variety of alkynes and acetylene gas was carried out using 100 to 800 mol ppm of Cu of PVPy-Cu in water, whose turnover numbers reached up to 10 000. This catalytic system was applied to the synthesis of tazobactam, which is an inhibitor of bacterial β-lactamases.

Huisgen cycloaddition with acetylene gas by using an amphiphilic self-assembled polymeric copper catalyst

A copper-mediated Huisgen cycloaddition, aka the copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC), of flammable acetylene gas and a variety of organic azides proceeded smoothly by using our amphiphilic self-assembled polymeric copper catalyst MPPI-C

Phase-Vanishing Method with Acetylene Evolution and Its Utilization in Several Organic Syntheses

A novel quadraphasic phase-vanishing system in which acetylene is evolved from calcium carbide and directly applied in situ to the Sonogashira coupling reaction was developed. This method, which provides a safe, convenient, and one-pot means to utilize gaseous reagents without special equipment, was also applied to a Cu-catalyzed azide-alkyne cycloaddition (CuAAC) reaction and a three-component aldehyde-alkyne-amine (A3) coupling reaction with excellent results. (Figure Presented).

Palladium-catalyzed oxidative C-H/C-H cross-coupling of 1-substituted 1,2,3-triazoles with furans and thiophenes

Palladium-catalyzed heteroarylation of 1-substituted 1,2,3-triazoles with furans and thiophenes has been developed in the presence of pyridine and Ag2CO3. The procedure is suitable for the regioselective preparation of 1,5-disubstitu

Easy one-pot synthesis of 1-monosubstituted aliphatic 1,2,3-triazoles from aliphatic halides, sodium azide and propiolic acid by a click cycloaddition/decarboxylation process

1-Monosubstituted aliphatic 1,2,3-triazoles were synthesized by a one-pot reaction from aliphatic halides (Cl and Br), sodium azide and propiolic acid. The yields ranged from moderate to good. The reaction was easily carried out in DMF with Cs2CO3 at 100°C by copper-catalyzed click cycloaddition/decarboxylation. The synthesis of 1-monosubstituted aliphatic 1,2,3-triazoles was achieved in a one-pot reaction from aliphatic halides (Cl, Br), sodium azide and propiolic acid with yields ranging from moderate to good. Copyright

Microwave irradiation as an effective means of synthesizing uninfstituted N-linked 1,2,3-triazoles from vinyl acetate and azides

N-Linked 1,2,3-triazoles have been prepared by a reaction of azides with vinyl acetate under microwave irradiation. Additionally, a microwave-assisted, two-step, one-pot procedure from halides involving azideinfstitution in diethyl ether, followed by -reaction with vinyl acetate, has effectively been employed. Georg Thieme Verlag Stuttgart - New York.