637774-19-7Relevant academic research and scientific papers
LIPID A ANTAGONISTS WITH ANTI-SEPTIC SHOCK, ANTI-INFLAMMATORY, ANTI-ISCHEMIA AND ANALGESIC ACTIVITY
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, (2008/06/13)
The present invention relates to compounds of general formula (I), wherein R1-R4 are as defined in the description, to processes for their preparation and to their use as medicaments. The compounds of formula (I) inhibit the effect o
Synthesis and biological evaluation of novel lipid A antagonists
Peri, Francesco,Marinzi, Chiara,Barath, Marek,Granucci, Francesca,Urbano, Matteo,Nicotra, Francesco
, p. 190 - 199 (2007/10/03)
A mimetic of Lipid A with a β-N(OMe) glycosidic linkage, four linear C-14 hydrophobic chains and without phosphate groups has been prepared together with its β-O-linked analogue. Both these molecules were active in inhibiting the inflammatory action of Es
