872677-64-0Relevant articles and documents
Trehalose- and glucose-derived glycoamphiphiles: Small-molecule and nanoparticle toll-like receptor 4 (TLR4) modulators
Rodriguez Lavado, Julio,Sestito, Stefania E.,Cighetti, Roberto,Aguilar Moncayo, Eva M.,Oblak, Alja,Lain??ek, Du?ko,Jiménez Blanco, José Luis,García Fernández, José Manuel,Ortiz Mellet, Carmen,Jerala, Roman,Calabrese, Valentina,Peri, Francesco
, p. 9105 - 9123 (2014)
An increasing number of pathologies have been linked to Toll-like receptor 4 (TLR4) activation and signaling, therefore new hit and lead compounds targeting this receptor activation process are urgently needed. We report on the synthesis and biological pr
LIPID A ANTAGONISTS WITH ANTI-SEPTIC SHOCK, ANTI-INFLAMMATORY, ANTI-ISCHEMIA AND ANALGESIC ACTIVITY
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Page/Page column 10; 14-15, (2008/06/13)
The present invention relates to compounds of general formula (I), wherein R1-R4 are as defined in the description, to processes for their preparation and to their use as medicaments. The compounds of formula (I) inhibit the effect o