63789-85-5Relevant academic research and scientific papers
Bicyclic benzo fused compounds
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, (2008/06/13)
Bicyclic fused benzenoid compounds of the formula STR1 and pharmaceutically acceptable cationic and acid addition salts thereof, where M is O, CH2 or NR6 ; R6 is hydrogen, formyl, carbobenzyloxy or certain carboalkoxyalkyl, alkanoyl, alkyl, aralkyl or aralkylcarbonyl groups; A' is: (1) A where one of A and B is hydrogen such that when A is hydrogen, B is C(R2 R3)(CH2)f Q and f is 1 or 2; when B is hydrogen, A is C(R2 R3)(CH2)f Q and f is 0 or 1, when taken together A and OR1 form a lactone or certain derivatives thereof; (2) A' is STR2 (3) A' is Q3 ; Q is CO2 R7, COR8, C(OH)R8 R9, CN, CONR12 R13, CH2 NR12 R13, CH2 NHCOR14, CH2 NHSO2 R17 or 5-tetrazoyl; Q3 is STR3 5-tetrazolyl, CH2 CONHCOR7, COOH or certain ester, amide, carboximido or sulfonimido derivatives thereof, CONHOH, CONHCONH2, or COCH2 Q4 where Q4 is CN or COOH or certain esters thereof; R1 is hydrogen, benzyl or certain acyl groups; R4 is hydrogen, certain alkyl or certain aralkyl groups; R5 is hydrogen or certain alkyl groups; Z is (C1 -C9)alkylene, optionally interrupted by O, S, SO or SO2 ; and W is hydrogen, methyl, certain aryl or cycloalkyl groups; useful in mammals as analgesics, tranquilizers, antiemetic agents, diuretics, anticonvulsants, antidiarrheals, antitussives, in treatment of glaucoma, and intermediates therefore.
