63819-85-2Relevant academic research and scientific papers
SUBSTITUTED PYRROLIDINE AMIDES III
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Paragraph 0174-0175, (2020/07/25)
The invention relates to compounds according to general formula (I), which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.
Diastereoselective synthesis of 1,3,5- Trisubstituted 4-nitropyrrolidin-2- ones via a nitro-mannich/lactamization cascade
Pelletier, Sophie M.-C.,Ray, Peter C.,Dixon, Darren J.
supporting information; experimental part, p. 6406 - 6409 (2012/02/01)
A versatile one-pot nitro-Mannich/lactamization cascade for the direct synthesis of 1,3,5-trisubstituted 4-nitropyrrolidin-2-ones has been developed. The reaction is easy to perform and broad in scope, and high levels of diastereoselectivity can be achiev
Nitro as a novel zinc-binding group in the inhibition of carboxypeptidase A
Wang, Si-Hong,Wang, Shou-Feng,Xuan, Wei,Zeng, Zong-Hao,Jin, Jing-Yi,Ma, Jie,Tian, Guan Rong
, p. 3596 - 3601 (2008/12/20)
2-Substituted 3-nitropropanoic acids were designed and synthesized as inhibitors against carboxypeptidase A (CPA). (R)-2-Benzyl- 3-nitropropanoic acid showed a potent inhibition against CPA (Ki = 0.15 μM). X-ray crystallography discloses that t
α-Lithio quinuclidine N-oxide (Li-QNO): A new base for synthetic chemistry
O'Neil, Ian A.,Bhamra, Inder,Gibbons, Peter D.
, p. 4545 - 4547 (2008/09/19)
α-Lithio quinuclidine N-oxide (Li-QNO) behaves as a strong non-nucleophilic base and an HMPA mimetic in a tandem process, in a range of synthetically useful reactions. The Royal Society of Chemistry 2006.
Quinuclidine N-oxide: A potential replacement for HMPA
O'Neil, Ian A.,Lai, Justine Y. Q.,Wynn, Duncan
, p. 59 - 60 (2007/10/03)
The use of quinuclidine N-oxide as a replacement for HMPA is described.
Doubly Deprotonated Methyl 3-Nitropropanoate, an Acrylic Ester d2-Reagent
Seebach, Dieter,Henning, Rainer,Mukhopadhyay, Triptikumar
, p. 1705 - 1720 (2007/10/02)
Methyl 3-nitropropanoate can be doubly deprotonated with LDA, both in the α-nitro and in the α-carbonyl position (-> 1).It is shown that the necessary cosolvent HMPT can be replaced by the cyclic urea DMPU, with almost equal results.The new reagent 1 is alkylated and hydroxyalkylated by alkyl halides and aldehydes, respectively, at the 2-position exclusively (see 2, 4, 6, 7).A double alkylation to methyl α,α-dialkyl-β-nitropropanoate 5 is possible.Elimination of HNO2 with DBN or even better with DBU in THF furnishes methyl α-methylenealkanoates 9 and methyl β-hydroxy-α-methylenealkanoates 10.
