63833-47-6

Upstream product

• 109-97-7 pyrrole 
• 122-04-3 4-nitro-benzoyl chloride 
• 20671-52-7 lithium pyrrolide 
• 555-16-8 4-nitrobenzaldehdye 
• 100-19-6 (4-nitrophenyl)ethanone 
• 14922-36-2 4-nitrophenylglyoxylic acid 
• 619-73-8 4-nitrobenzyl chloride 
• 38480-28-3 2-bromo-1H-pyrrole 
• 62-23-7 4-nitro-benzoic acid 
• 5397-76-2 1-morpholin-4-yl-1-(4-nitro-phenyl)-methanone 

Downstream Products

• 154047-03-7 (1-Allyl-1H-pyrrol-2-yl)-(4-nitro-phenyl)-methanone 
• 199995-53-4 5-(4-Nitro-benzoyl)-1H-pyrrole-3-carbaldehyde 
• 199995-54-5 1-Ethyl-5-(4-nitro-benzoyl)-1H-pyrrole-3-carbaldehyde 
• 199995-56-7 1-ethyl-5-(4-nitrobenzoyl)-3-(4-hydroxy-1-butenyl)-1H-pyrrole 
• 199995-57-8 4-[1-ethyl-5-(4-nitrobenzoyl)-1H-pyrrole-3-yl]butanol 
• 200344-90-7 4-[1-ethyl-5-(4-nitrobenzoyl)-1H-pyrrol-3-yl]butyric acid 
• 199995-55-6 1-ethyl-5-(4-nitrobenzoyl)-3-(4-tetrahydropyranyloxy-1-butenyl)-1H-pyrrole 
• 154047-22-0 (1-Allyl-1H-pyrrol-2-yl)-(4-nitro-phenyl)-methanol 
• 1445098-30-5 4,4-difluoro-1,3-dimethyl-8-(4-nitrophenyl)-4-bora-3a,4a-diaza-s-indacene 
• 1445098-35-0 4,4-difluoro-1,3-dimethyl-8-(4-aminoophenyl)-4-bora-3a,4a-diaza-s-indacene 

Relevant academic research and scientific papers

Synthesis of Three New Tricyclic Ring Systems: Pyrrolotriazepines Condensed with an Imidazole, a Triazole, or a Tetrazole Ring

In a previous paper, we have disclosed a practical synthesis of 1-aryl-3H-pyrrolo[2,1-d][1,2,5]triazepin-4(5H)-ones. Now, these compounds have been used as the starting materials for the synthesis of three new ring systems, pyrrolotriazepines condensed wi

Aroylation of Electron-Rich Pyrroles under Minisci Reaction Conditions

The development of Minisci acylation on electron-rich pyrroles under silver-free neutral conditions has been reported featuring the regioselective monoacylation of (NH)-free pyrroles. Unlike conventional Minisci conditions, the avoidance of any acid that could result in the polymerization of pyrroles was the key to success. The umpolung reactivity of the nucleophilic acyl radical, generated in situ from arylglyoxylic acid, could help explain the mechanism of product formation with electron-rich pyrroles. Alternatively, the nucleophilic substitution of the acyl radical on the electron-deficient pyrrole radical cation is proposed.

CDy14: A novel biofilm probe targeting exopolysaccharide Psl

Detection of biofilm bacteria would be an ideal method for the physicians to diagnose chronic bacterial infections directly, but there are few imaging probes available so far. Here, we report the development of a novel biofilm detecting fluorescent probe, CDy14, through an unbiased screening of a fluorescence library and elucidated its binding partner Psl, an exopolysaccharide of the biofilm.

Detection of Pathogenic Biofilms with Bacterial Amyloid Targeting Fluorescent Probe, CDy11

Bacterial biofilms are responsible for a wide range of persistent infections. In the clinic, diagnosis of biofilm-associated infections relies heavily on culturing methods, which fail to detect nonculturable bacteria. Identification of novel fluorescent probes for biofilm imaging will greatly facilitate diagnosis of pathogenic bacterial infection. Herein, we report a novel fluorescent probe, CDy11 (compound of designation yellow 11), which targets amyloid in the Pseudomonas aeruginosa biofilm matrix through a diversity oriented fluorescent library approach (DOFLA). CDy11 was further demonstrated for in vivo imaging of P. aeruginosa in implant and corneal infection mice models.

CHEMICAL FLUORESCENT PROBES FOR DETECTING BIOFILMS

The present invention relates to a family of fluorescent compounds based on the BODIPY scaffold, and methods for the preparation of said compounds. The present invention further relates to the use of said compounds for the detection of bacterial biofilms, wherein the bacterial biofilm comprises Pseudomonas aeruginosa and the compound specifically binds to a Fap protein of Pseudomonas aeruginosa, or wherein the compound specifically binds to bacterial cells that contain high levels of cyclic-di-guanosine-monophosphate (c-di-GMP).

Method for synthesizing drug intermediate pyrrolidone compound

The invention relates to a method for synthesizing a pyrrolidone compound which can be used as a drug intermediate as shown in a formula (III). The method comprises the following steps: reacting a compound as shown in a formula (I) with a compound as shown in a formula (II) in the presence of a catalyst, an organic ligand, an oxidant, an adjuvant and alkali in an organic solvent under a nitrogen atmosphere, and performing post-treatment after the reaction is completed to obtain the compound as shown in the formula (III), wherein R is H, C1-C6 alkyl, C1-C6 alkoxy, halogen or nitro. According to the method, a comprehensive reaction system of catalyst, ligand, oxidant, alkali and solvent is adopted, so that a target product is obtained with high yield. The pyrrolidone compound has an excellent application prospect and industrial production potential in the technical field of organic synthesis, especially drug intermediate synthesis.

Synthesis of 2-benzoylpyrrole derivatives via C-H functionalization adjacent to nitrogen of pyrrole

A direct transition-metal-free synthesis of 2-benzoylpyrrole derivatives from free (N-H) pyrroles and benzaldehyde has been developed. The benzoylation reaction at the 2 or 5-position of pyrrole proceeded well under the alkali metalation system and with 2

Facile Synthesis of 9,10,19,20-Tetraarylporphycenes

A simple route was developed for the synthesis of 9,10,19,20-tetraarylporphycenes by combining both McMurry and oxidative synthetic strategies and using readily available precursors. The desired 5,6-diaryldipyrroethenes, which were prepared in multigram quantities over two steps, were used to prepare 9,10,19,20-tetraarylporphycenes under mild acid-catalyzed conditions. As 5,6-diaryldipyrroethene precursors can easily be prepared in multigram quantities, this method is useful for the preparation of meso-tetrarylporphycenes that contain different aryl substituents. The molecular structures of these macrocycles were determined by HRMS analysis as well as 1D and 2D NMR studies. The tetraarylporphycenes exhibited a strong Soret band at approximately 380 nm and three Q bands in the region of 580-655 nm. The tetraarylprophycenes are reasonably fluorescent and stable under redox conditions. A simple, rapid method was developed for the synthesis of meso-tetraarylporphycenes by employing a McMurry coupling followed by an oxidation reaction as the key steps. This synthetic strategy uses readily available precursors to afford 9,10,19,20-tetraarylporphycenes. The absorption, fluorescence, and electrochemical properties of these macrocycles were also studied.

BODIPY STRUCTURE FLUORESCENCE PROBES FOR DIVERSE BIOLOGICAL APPLICATIONS

The present invention is directed to a fluorescence compound represented by structural Formula (I), with specificity to neural stem cells: (I), or a pharmaceutically acceptable salt thereof. The variables for structural Formula (I) are defined herein. Als

Visualization and isolation of langerhans islets by a fluorescent probe PiY

Lighting up the pancreas: A pancreatic beta cell selective probe PiY (red, see picture) was developed which stains Langerhans islets in live animals without toxicity or side effects. Through tail-vein injection, PiY allowed for a comparison of the islets between healthy and diabetic mice. PiY also facilitated the isolation of healthy Langerhans islets by using a fluorescence-guided surgical procedure. Copyright