63834-59-3Relevant academic research and scientific papers
INSECTICIDAL BIS(SUBSTITUTED PHENYL)-1-{[4-(SATURATED HETEROCYCLYL-SUBSTITUTED)PHENYLMETHYL]-(4-PIPERIDYL)}METHANE DERIVATIVES
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Page/Page column 23; 37-38, (2008/06/13)
It has now been found that certain novel bis(substituted phenyl)-1- {[4-(saturated heterocyclyl-substituted)phenylmethyl](4-piperidyl)}methane derivatives have provided unexpected insecticidal activity. These compounds are represented by formula (I); where R through R15,m, n, s, A, B, D and W are defined herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula (I), and optionally, an effective amount of at least one of a second compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.
Cyclic sulfites, key intermediates in synthesis of 1-alkylamino-3-aryloxy-2-propanols from glycidol
Bredikhina,Savel'ev,Bredikhin
, p. 213 - 219 (2007/10/03)
A number of 3-aryloxypropanedioles were obtained by treating glycidol with phenols. The latter with thionyl chloride afforded 4-aryloxymethyl-1,3,2-dioxathiolane 2-oxides. These compounds were also obtained from 4-chloromethyl-1,3,2-dioxathiolane 2-oxides by substitution aryloxy group for chlorine. The cyclic sulfides synthesized are universal intermediates in the synthesis of chiral aryloxypropanolamines among which are known β-adrenoblockaders, cardiovascular drugs. From (S)-glycidol, (S)-alprenolol, (S)-propanolol, and (S)-thymolol were synthesized.
Design of liquid crystalline block molecules with nonconventional mesophase morphologies: Calamitic bolaamphiphiles with lateral alkyl chains
Koelbel,Beyersdorff,Xiao Hong Cheng,Tschierske,Kain,Diele
, p. 6809 - 6818 (2007/10/03)
Novel bolaamphiphiles, consisting of a biphenyl rigid core, polar 2,3-dihydroxypropoxy groups at each terminal end, and an additional long alkyl chain in a lateral position have been synthesized. The structures of these ternary block molecules were systematically changed by variation of the length and position of the alkyl chain, by introduction of additional spacer units between one of the 2,3-dihydroxypropyl groups and the rigid core, and by replacement of one of the 2,3-dihydroxypropoxy groups by a single hydroxy group. The influence of these structural variations on the liquid crystalline properties of these new materials was investigated by polarized-light microscopy, differential scanning calorimetry, and X-ray diffraction. These investigation have shown that, by elongation of the lateral chain, a transition from a smectic monolayer structure (SmA1) via a strongly distorted layer structure (SmA+), a centered rectangular columnar phase (Colr/c2mm) and a noncentered rectangular columnar phase (Colr/p2gg) to a hexagonal columnar phase (Colh/p6mm) takes place. Elongation of the bolaamphiphilic core leads to the loss of the columnar phases, which are replaced by smectic phases, whereas reduction of its length favors the hexagonal columnar phase. This phase sequence is explained as a result of the microsegregation of the lateral alkyl chains from the rigid aromatic cores. The segregated alkyl chains are organized in columns that interrupt the smectic layers. The hydrogen bonding keep the bolaamphiphilic cores fixed end to end, so that they form networks of cylinders around the lipophilic columns. The space required by the alkyl chains with respect to the length of the bolaamphiphilic cores is restricted and largely determines the geometry of the cylinders, which leads to the observed phase sequence. The obtained mesophase morphologies, built up by three distinct sets of subspaces, are related to morphologies of some ternary block copolymers. Furthermore, the investigated compounds represent a novel class of materials, capable of forming supramolecular columnar mesophases.
Thermotropic and lyotropic liquid crystalline phases of rigid aromatic amphiphiles
Koelbel, Marius,Beyersdorff, Tom,Tschierske, Carsten,Diele, Siegmar,Kain, Jens
, p. 3821 - 3837 (2007/10/03)
Rodlike amphiphilic molecules that contain exclusively aromatic building-blocks and no flexible alkyl chains have been synthesized and their mesomorphic properties investigated. These novel compounds bear diol head groups of different size (2,3-dihydroxypropyloxy or 5,6-dihydroxy-3-oxahexyloxy groups) at one end of a biphenyl unit, various aromatic segments (benzyloxy, 4-, 3-, or 2-methylbenzyloxy, phenoxy groups) at the other, and additional methyl substituents in different positions. They were synthesized by using Suzuki cross-coupling reactions as the key steps. Their thermotropic mesomorphism was investigated by means of polarized light optical microscopy, differential scanning calorimetry, and, for enantiotropic phases, by X-ray scattering. The liquid crystallinity of this class of compounds is influenced by protic solvents, such as water and glycerol. Dependent on the temperature and the solvent content, different SA phases were found. Several mesophases resulting from the frustration of these layer structures (e.g., different columnar phases, optical isotropic mesophases, and nematic phases) were also present. The smectic phases have different degrees of intercalation (SAd, SA2). The columnar phases are supposed to be ribbon structures that result from the collapse of the smectic layers. They occur in some pure compounds or they are induced upon the addition of protic solvents. The particular phase sequences of the different compounds depend mainly on the position of the methyl substituents at the biphenyl cores and are largely determined by the degree of intercalation of the aromatic cores.
Novel Water-Soluble Organosilane Compounds as a Radical Reducing Agent in Aqueous Media
Yamazaki, Osamu,Togo, Hideo,Nogami, Genki,Yokoyama, Masataka
, p. 2519 - 2523 (2007/10/03)
The development of novel water-soluble organosilane compounds and their application to radical reactions in water medium have been studied. A series of novel organosilane compounds having hydrophilic groups, such as an ether group and a hydroxy group in the side chain to bear hydrophilicity, were synthesized by the reaction of trichlorosilane or tetrachlorosilane and Grignard reagents. The reactivities of these organosilane compounds were studied in the radical reduction of 2-bromoethyl phenyl ether in ethanol in the presence of triethylborane under aerobic conditions. The results showed that diarylsilane was the most effective among them. The radical reduction of alkyl and aryl halides with diarylsilane was applied to a reaction in aqueous media, which gave the corresponding reduction product in good yields. Thus, the present organosilanes are very useful for the reduction of water-soluble substrates, such as halo sugars in water.
