63834-83-3

Basic information

• Product Name: guaietolin
• Synonyms: 3-(o-Ethoxyphenoxy)-1,2-propanediol;Guethral;guaietolin;3-(2-Ethoxyphenoxy)propane-1,2-diol;Guaietoline
• CAS NO: 63834-83-3
• Molecular Formula: C₁₁H₁₆O₄
• Molecular Weight: 212.24234
• EINECS: 264-504-4
• Mol File: 63834-83-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 65-66 °C(Solv: hexane (110-54-3))
• Boiling Point: 368.1°C at 760 mmHg
• Flash Point: 176.4°C
• Appearance: /
• Density: 1.163g/cm³
• Vapor Pressure: 4.57E-06mmHg at 25°C
• Refractive Index: 1.532
• PKA: 13.53±0.20(Predicted)
• CAS DataBase Reference: guaietolin(CAS DataBase Reference)
• NIST Chemistry Reference: guaietolin(63834-83-3)
• EPA Substance Registry System: guaietolin(63834-83-3)

Safety Data

• Hazardous Substances Data: 63834-83-3(Hazardous Substances Data)

Usage

General Description

Guaietolin, also known as 3,3',4',5-Tetrahydroxyflavone, is a natural flavonoid compound found in the heartwood of several plant species such as Acacia catechu, Dalbergia cultrata, and Guaiacum. It has been shown to possess various biological activities, including antioxidant, anti-inflammatory, and anticancer properties. Guaietolin has been found to inhibit the growth of cancer cells and induce apoptosis, making it a potential candidate for the development of new cancer therapies. Additionally, its antioxidant and anti-inflammatory properties make it a promising compound for the treatment of oxidative stress-related diseases and inflammatory conditions. Overall, guaietolin is a valuable natural compound with potential therapeutic applications in various fields.

InChI:InChI=1/C11H16O4/c1-2-14-10-5-3-4-6-11(10)15-8-9(13)7-12/h3-6,9,12-13H,2,7-8H2,1H3

Upstream product

• 94-71-3 2-Ethoxyphenol 
• 556-52-5 oxiranyl-methanol 
• 120-80-9 benzene-1,2-diol 
• 96-24-2 3-monochloro-1,2-propanediol 
• 74-96-4 ethyl bromide 
• 19826-87-0 3-(2-hydroxy-phenoxy)-propane-1,2-diol 

Downstream Products

• 137208-72-1 Sulfamic acid 3-(2-ethoxyphenoxy)-1,2-propanediyl ester 
• 137208-76-5 Methylsulfamic acid 3-(2-ethoxyphenoxy)-1,2-propanediyl ester 

Relevant articles and documents

Spontaneous resolution among chiral glycerol derivatives: crystallization features of ortho-alkoxysubstituted phenyl glycerol ethers

Five chiral arylglycerol ethers 2-R-C6H4-O-CH2CH(OH)CH2OH (R = OMe, OEt, OPrn, OPri, OBut) have been prepared in racemic and enantiopure form. The melting points and enthalpies of fusion of every species were measured by differential scanning calorimetry. Binary phase diagrams were reconstructed for the whole family, the entropies of the mixing of the enantiomers in the liquid state, and Gibbs free energy of formation of the racemic compound, as well as Pettersson i-values were derived from the thermal data. The differences in the phase behavior of the investigated compounds were associated with the conformations of the alkoxy fragments.

Compounds having one or more aminosulfaonyloxy radicals useful as pharmaceuticals

Methods of treating chronic arthritis and osteoporosis which utilize both known and novel compounds which would fall under the general formula:(HO)p--A--[--OS(O) 2 NR 1 R 2 ] zwherein A encompasses a wide range of values including but not limited to aryl, loweralkyl, cycloalkyl, and carbohydrates including sucrose and fructose; p is equal to the number of unreacted hydroxy groups contained on the molecule and may be zero; z is the number of --OS(O) 2 NR 1 R 2 groups and is always at least one; R 1 and R 2 are selected from hydrogen, loweralkyl, carboxy and the like; a novel process for preparing the compounds is provided wherein an appropriate sulfamic acid aryl ester is reacted with a hydroxy substituted A radical which may or may not contain thereon protected carboxyl, amino or hydroxy substituents, in an aprotic solvent containing a tertiary amine base. Pharmaceutical compositions for the treatment of chronic arthritis and osteoporosis are also provided.