63867-13-0

Basic information

• Product Name: 4-(Diethylamino)butyric acid
• Synonyms: 4-(Diethylamino)butyric acid;DF-472
• CAS NO: 63867-13-0
• Molecular Formula: C₈H₁₇NO₂
• Molecular Weight: 159.23
• Mol File: 63867-13-0.mol

Chemical Properties

• Melting Point: 166 °C
• Boiling Point: 255.1°Cat760mmHg
• Flash Point: 108.1°C
• Appearance: /
• Density: 0.98g/cm³
• Vapor Pressure: 0.00511mmHg at 25°C
• Refractive Index: 1.458
• PKA: 4.42±0.10(Predicted)
• CAS DataBase Reference: 4-(Diethylamino)butyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Diethylamino)butyric acid(63867-13-0)
• EPA Substance Registry System: 4-(Diethylamino)butyric acid(63867-13-0)

Safety Data

• Hazardous Substances Data: 63867-13-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H17NO2/c1-3-9(4-2)7-5-6-8(10)11/h3-7H2,1-2H3,(H,10,11)

Upstream product

• 63918-33-2 ethyl 4-(diethylamino)butanoate 
• 628-20-6 4-Chlorobutyronitrile 
• 109-89-7 diethylamine 
• 90726-85-5 methyl 4-(diethylamino)butanoate 
• 173253-06-0 benzyl 4-(N,N-diethylamino)butanoate 

Downstream Products

• 2687-91-4 1-ethyl-2-pyrrolidinone 
• 28341-54-0 4-(4-nitrophenoxy)butanoic acid 
• 109-89-7 diethylamine 

Relevant articles and documents

Carbamate as an accelerating group in intermolecular Pauson-Khand reaction

The Pauson-Khand reaction (PKR) is a powerful means for the construction of cyclopentenones. However, its applications have been limited to the intramolecular version of this reaction because poor yield and regioselectivity are often the major problems in intermolecular PKR. Here we describe that a carbamate moiety in alkene substrate accelerates this intermolecular PKR. The reaction of N-4-dimethylaminophenyl O-allyl carbamate with alkyne-cobalt complex gave cyclopentenones in high yield (up to 90%) and regioselectivity (>9:1).

LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS

This invention provides for a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein RA, RB, R2 and R4 are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.

Pharmaceutical composition containing quinoline or quinazoline derivatives and derivatives therefor

This invention provides an anti-inflammatory agent, particularly an agent for treating arthritis, containing a quinoline or quinazoline derivative or a salt thereof STR1 wherein Y is a nitrogen atom or C--G in which G is an optionally esterified carboxyl group;R 1 and R 2 are each independently a hydrogen atom, optionally substituted hydrocarbon group or optionally substituted heterocyclic group, or R 1 and R 2 are linked together to form a saturated ring;each of the ring A and ring B may optionally be substituted;n is an integer of 1 to 4; andk is 0 or 1.This invention also provides a novel quinoline or quinazoline derivative having anti-inflammatory activity.