639091-78-4

Basic information

• Product Name: (4-AMINOMETHYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER
• Synonyms: RARECHEM AL BW 2482;(4-AMINOMETHYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER;2-(Boc-amino)-4-(aminomethyl)pyridine;tert-butyl N-[4-(aMinoMethyl)pyridin-2-yl]carbaMate
• CAS NO: 639091-78-4
• Molecular Formula: C₁₁H₁₇N₃O₂
• Molecular Weight: 223.27
• Mol File: 639091-78-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 131-132 °C
• Boiling Point: 321.9°C at 760 mmHg
• Flash Point: 148.5°C
• Appearance: /
• Density: 1.164g/cm³
• Vapor Pressure: 0.000289mmHg at 25°C
• Refractive Index: 1.567
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 12.42±0.70(Predicted)
• CAS DataBase Reference: (4-AMINOMETHYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (4-AMINOMETHYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER(639091-78-4)
• EPA Substance Registry System: (4-AMINOMETHYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER(639091-78-4)

Safety Data

• Hazardous Substances Data: 639091-78-4(Hazardous Substances Data)

Usage

General Description

The chemical (4-aminomethyl-pyridin-2-yl)-carbamic acid tert-butyl ester is a compound with the molecular formula C11H17N3O2. It is a carbamic acid ester derivative and is commonly used in the pharmaceutical and agricultural industries. This chemical has a variety of applications, including as a building block in the synthesis of various compounds and as a reagent in organic chemical reactions. It is important to handle this chemical with care, as its toxicity and potential hazards are not yet fully understood.

InChI:InChI=1/C11H17N3O2/c1-11(2,3)16-10(15)14-9-6-8(7-12)4-5-13-9/h4-6H,7,12H2,1-3H3,(H,13,14,15)

Upstream product

• 856897-86-4 (4-azidomethyl-pyridin-2-yl)-carbamic acid tert-butyl ester 
• 13362-28-2 2-aminoisonicotinic acid 
• 6313-54-8 2-chloroisonicotinic acid, 
• 639091-76-2 {2-[(tert-butoxycarbonyl)amino]pyridin-4-yl}methyl methanesulfonate 
• 639091-75-1 methyl 2-[(tert-butoxycarbonyl)amino]isonicotinate 
• 304873-62-9 (4-hydroxymethylpyridin-2-yl)carbamic acid tert-butyl ester 
• 639091-77-3 tert-butyl {4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]pyridin-2-yl}carbamate 

Relevant articles and documents

Discovery of an N-(2-aminopyridin-4-ylmethyl)nicotinamide derivative: A potent and orally bioavailable NCX inhibitor

Ca2+ overload in myocardial cells is responsible for arrhythmia. Sodium-calcium exchanger (NCX) inhibitors are more effective than sodium-hydrogen exchanger (NHE) inhibitors with regard to modulation of Ca 2+ overload, because NCX inhibitors can directly inhibit the influx of Ca2+ into cells. NCX is an attractive target for the treatment of heart failure and ischemia-reperfusion. We have designed and synthesized a series of N-(2-aminopyridin-4-ylmethyl)nicotinamide derivatives, based on compound 5. We have discovered a novel NCX inhibitor (23h) with an IC 50 value of 0.12 μM against reverse NCX. The inhibitory activities of our NCX inhibitors against cytochrome P450 were also evaluated. The effects on heart failure and the pharmacokinetic profile of compound 23h are discussed.

NEW 5,6-DIHYDROPYRIN-2-ONE COMPOUNDS USEFUL AS INHIBITORS OF THROMBIN

There is provided a compound of formula (I) wherein R1, R2a, R2b, R3a, R3b, R4, R5, R6, A, G and L have meanings given in the description, which compounds are useful a