6392-97-8

Basic information

• Product Name: 2-Phenyl-benzothiazol-6-ylamine
• Synonyms: 2-Phenylbenzo[d]thiazol-6-amine
• CAS NO: 6392-97-8
• Molecular Formula: C₁₃H₁₀N₂S
• Molecular Weight: 226.297
• Mol File: 6392-97-8.mol
• Article Data: 9

Chemical Properties

• Melting Point: 206-207 °C
• Boiling Point: 430.9 °C at 760 mmHg
• Flash Point: 214.4 °C
• Appearance: /
• Density: 1.301 g/cm³
• PKA: 2?+-.0.10(Predicted)
• CAS DataBase Reference: 2-Phenyl-benzothiazol-6-ylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Phenyl-benzothiazol-6-ylamine(6392-97-8)
• EPA Substance Registry System: 2-Phenyl-benzothiazol-6-ylamine(6392-97-8)

Safety Data

• Hazardous Substances Data: 6392-97-8(Hazardous Substances Data)

Usage

General Description

2-Phenyl-benzothiazol-6-ylamine is a chemical compound with the molecular formula C14H11NOS. It is a member of the benzothiazole family and consists of a benzothiazole ring with an attached phenyl group and an amine functional group. 2-Phenyl-benzothiazol-6-ylamine is used in organic synthesis and pharmaceutical research as a building block for the production of various compounds with potential biological activity. It can also be used as a probe in studies of enzyme kinetics and drug receptor interactions. The compound may have potential applications in the development of new drugs and therapeutic agents due to its structural and functional properties.

Upstream product

• 64-17-5 ethanol 
• 93930-09-7 thiosulfuric acid S-(2,5-diamino-phenyl ester) 
• 100-52-7 benzaldehyde 
• 2516-37-2 2-bromo-6-nitro-benzo[d]thiazole 
• 945400-80-6 2-bromanyl-1,3-benzothiazol-6-amine 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 6285-57-0 2-amino-6-nitrobenzothiazole 
• 533-30-2 1,3-benzothiazol-6-amine 
• 108-86-1 bromobenzene 
• 95-16-9 1,3-Benzothiazole 
• 2942-06-5 6-nitrobenzo[d]thiazole 
• 98-88-4 benzoyl chloride 
• 23451-98-1 2-amino-5-nitrobenzenethiol 
• 38338-23-7 6-nitro-2-phenyl-benzothiazole 

Downstream Products

• 1426262-55-6 C₂₈H₃₄N₄OS₂ 
• 1426262-52-3 C₂₈H₃₂N₄O₂S₂ 
• 1426262-48-7 C₁₅H₁₁ClN₂OS 
• 863770-37-0 N-(2-phenylbenzothiazol-6-yl)acetamidine 

Relevant articles and documents

Oxidative C-H Homocoupling of Push-Pull Benzothiazoles: An Atom-Economical Route to Highly Emissive Quadrupolar Arylamine-Functionalized 2,2′-Bibenzothiazoles with Enhanced Two-Photon Absorption

Copper(II)-catalyzed C-H/C-H coupling of dipolar 2-H-benzothiazoles end-capped with triphenylamine moieties affords highly fluorescent 2,2′-bibenzothiazoles with quadrupolar (D-π-A-π-D) architecture displaying large two-photon absorption (TPA) cross sections (543-1252 GM) in the near-infrared region. The notably higher TPA performance as compared to quadrupolar π-systems with a widely used 2,2′-bipyridine core, along with the ease of the synthesis and chelating N^N ability, makes the title biheteroaryl platform an attractive building block for a large scope of functional dyes exploiting nonlinear optical phenomena.

NOVEL HYDRAZONE DERIVATIVE WITH ARYL OR HETEROARYL GROUP SUBSTITUTED AT TERMINAL AMINE GROUP THEREOF AND USE THEREOF

The present invention relates to novel hydrazone derivatives in which a terminal amine group is substituted with an aryl group or a heteroaryl group, and uses thereof.

Design, synthesis and structure-activity relationship of rhenium 2-arylbenzothiazoles as β-amyloid plaque binding agents

To continue our efforts toward the development of 99mTc PiB analogs, we have synthesized 24 neutral and lipophilic Re (as a surrogate of 99mTc) 2-arylbenzothiazoles, and explored their structure-activity relationship for binding to Aβ1-40 fibrils. These Re complexes were designed and synthesized via the integrated approach, so their 99mTc analogs would have a greater chance of crossing the blood-brain barrier. While the lipophilicities (log PC18 = 1.59-3.53) of these Re 2-arylbenzothiazoles were all within suitable range, their binding affinities (Ki = 30-617 nM) to Aβ1-40 fibrils varied widely depending on the selection and integration of the tetradentate chelator into the 2-phenylbenzothiazole pharmacophore. For potential clinical applications, further refinement to obtain Re 2-arylbenzothiazoles with better binding affinities (99mTc analogs for more widespread application via the use of SPECT scanners.