6394-52-1

Upstream product

• 1075-06-5 2,2-dihydroxy-1-phenyl-ethanone 
• 106-47-8 4-chloro-aniline 
• 98-86-2 acetophenone 
• 1074-12-0 phenylglyoxal hydrate 
• 91851-05-7 2-<(4-chlorophenyl)amino>-2-methoxy-1-phenylethanone 
• 53181-22-9 2-[(4-chlorophenyl)amino]-1-phenylethanone 
• 546-67-8 lead(IV) tetraacetate 

Downstream Products

• 112930-47-9 2-benzoyl-6-chloro-4-methoxy-3-methyl-1,2,3,4-tetrahydroquinoline 
• 89882-01-9 NSC 604519 
• 1256650-04-0 C₁₆H₁₂ClNO₂S 
• 1610600-24-2 (5-((4-chlorophenyl)amino)-3-methyl-1,6-diphenyl-1H-pyrazolo[3,4-b]pyridin-4-yl)(phenyl)methanone 
• 107209-65-4 (2-Chloro-7,8,9,10-tetrahydro-phenanthridin-6-yl)-phenyl-methanone 
• 107209-62-1 2-Chloro-6-benzoyl-7,8-dihydrophenanthridine 
• 107209-58-5 (8-Chloro-2,3-dihydro-1H-cyclopenta[c]quinolin-4-yl)-phenyl-methanone 
• 107209-54-1 8-Chloro-4-benzoyl-3a,9b-dihydro-3H-cyclopentaquinoline 
• 107209-57-4 8-Chloro-4-benzoyl-1H-cyclopentaquinoline 
• 107209-63-2 (2-chlorophenanthridin-6-yl)(phenyl)methanone 
• 107209-56-3 8-Chloro-4-benzoyl-3H-cyclopentaquinoline 
• 112930-49-1 2-benzoyl-6-chloro-3-dibromomethylquinoline 
• 112930-48-0 2-benzoyl-6-chloro-3-methylquinoline 
• 628718-87-6 2-[(4-chloro-phenyl)-(oxo-phenyl-acetyl)-amino]-N-cyclohexyl-3-oxo-3-phenyl-propionamide 

Relevant academic research and scientific papers

Reductive Alkylation of α-Keto Imines Catalyzed by PTSA/FeCl3: Synthesis of Indoles and 2,3′-Biindoles

A simple and efficient method for the synthesis of highly functionalized indoles and biindoles was developed. In the reaction protocol, three components were used in one pot and products were obtained in high yield in an easy workup procedure. The reactio

Antifungal activities of ketoazomethines of phenyl glyoxal and p-substituted anilines

A new series of ketoazomethines were synthesized by condensation of phenyl glyoxal (prepared by partial oxidation of acetophenone) with various p-substituted anilines viz. p-Cl, p-Br, p-NO2, p-(C2H 5)2N and p-CH

Synthesis and antifungal activity of 2-Ketophenyl-3 substituted aryl-1-thiazolidin-4-ones

A new series of 2-ketophenyl-3-substituted aryl-1- thiazolidin-4- ones were synthesized by cyclocondensation of ketoazomethines and thioglycolic acid. Ketoazomethines were synthesized by condensation of phenyl glyoxal (prepared by partial oxidation of ace

Studies on isocyanides and related compounds: A facile synthesis of 1,6-dihydro-6-oxopyrazine-2-carboxylic acid derivatives via Ugi four-component condensation

The Ugi four-component condensation (U-4CC) between arylglyoxals 7, amines 6, benzoylformic acid (4) and isocyanides 5 afforded the expected products 8 which were cyclized in a 5+1 fashion with ammonium acetate to give 1,N-disubstituted 4-aryl-1,6-dihydro-6-oxo-5-phenylpyrazine-2-carboxamides 9 in good yields. Evidence for the assigned structures 9 was provided by 13C NMR spectra and X-ray analysis of 9a.

Studies on isocyanides and related compounds: A novel synthesis of pyrroles via Ugi reaction

A series of N-substituted 1,3-diaryl-4-cyano-2,5-dihydro-5-oxopyrrole-2-carboxamides 9 is obtained by reacting arylglyoxal anils 6 with isocyanides 3 and cyanoacetic acid (2). Compounds 9 react quickly with diazomethane to give N-substituted 1,3-diaryl-4-

The Reaction of Phenylglyoxal with Primary Aliphatic and Aromatic Amines. Synthesis of Phenylglyoxal Monoimines and some Derivatives.

Condensation of phenylglyoxal with primary aliphatic amines yields the related keto-aldimines.When primary aromatic amines are used, aldimines, amino-hydroxy-ketones, diamino-ketones, and alkoxy-amino-ketones are obtained depending upon the nature of the amine and the experimental conditions.Alternatively the monoimines can be obtained by dehydration of C-hydroxyphenacylarylamines and by demethanolation of C-methoxyphenacylarylamines both on treatment with Pd/C catalyst.Reduction of phenylglyoxal monoimines with sodium borohydride yielded H-substituted 1-phenyl-2-aminoethanols and 1,3-dipolar cycloaddition of the imines with p-chlorobenzonitrile oxide afforded 4-substituted 5-benzoyl-3-(p-chlorophenyl)-4,5-dihydro-1,2,4-oxadiazoles.

SYNTHESIS AND REACTIONS OF PHENYLGLYOXAL ANILS

Contrary to previous reports, the reaction of anilines and phenylglyoxal in toluene affords the expected anil PhCO-CH=N-Ar, 1.In many cases it is more convenient to carry out the reaction in methanol where the methanol adduct of 1 forms, which may be better isolated, characterised and stored.Since the alcohol adduct is in equilibrium with free 1, it can be used for synthetic purposes as precursor of 1 as in hydrolysis, Diels-Alder, and other reactions initiated by nucleophilic attack on the carbon-nitrogen double bond.

Oxidation of Phenacylanilines with Lead Tetraacetate

Oxidation of phenacylanilines (Ia-d) with lead tetraacetate in dry benzene gives the corresponding anils (IIa-d) and N-acetyl derivatives (IIIa-d) of phenacylanilines.