639468-33-0

Upstream product

• 118156-93-7 3-formylpiperidine-1-carboxylic acid tert-butyl ester 
• 639468-28-3 3-(4-fluorobenzoyl)piperidine-1-carboxylic acid ethyl ester 
• 149452-46-0 (4-fluorophenyl)piperidin-3-ylmethanone 
• 769907-38-2 1-benzyl-piperidine-3-carbonyl chloride 
• 71962-74-8 Ethyl nipecotate 
• 72551-53-2 ethyl 1-benzylpiperidine-3-carboxylate 
• 141943-04-6 1-benzylpiperidine-3-carboxylic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 639468-31-8 3-(4-fluorobenzoyl)piperidine-1-carboxylic acid tert-butyl ester 
• 352-13-6 4-flourophenylmagnesium bromide 

Downstream Products

• 639468-31-8 3-(4-fluorobenzoyl)piperidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

AMINOPYRROLOTRIAZINES AS KINASE INHIBITORS

The disclosure relates to compounds of formula I which are useful as kinase modulators including RIPK1 modulation. The disclosure also provides methods of making and using the compounds for example in treatments related to necrosis or inflammation as well as other indications.

AMINOIMIDAZOPYRIDINES AS KINASE INHIBITORS

Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof, (I) are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.

AMINOTRIAZOLOPYRIDINES AS KINASE INHIBITORS

Compounds having formula (I) (IX), and enantiomers, and diastereomers, stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein: (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX).

Syntheses and Binding Studies of New [(Aryl)(aryloxy)methyl]piperidine Derivatives and Related Compounds as Potential Antidepressant Drugs with High Affinity for Serotonin (5-HT) and Norepinephrine (NE) Transporters

In a wide search program toward new, efficient, and fast-acting antidepressant drugs, we have prepared series of new compounds having an (aryl)(aryloxy)methyl moiety linked directly or through a methylene chain to different substituted and unsubstituted cycles (isoquinoline, piperazine, piperidine, tetrahydropyran, or cyclopentane). These compounds have been evaluated for their affinities for serotonin (5-HT) transporter (SERT) and 5-HT1A and 5-HT2A receptors. Racemic mixtures of 4-[(aryl)(aryloxy)methyl]piperidine derivatives showed much higher affinity values for SERT than fluoxetine and resulted in lack of affinity for 5-HT 1A and 5-HT2A receptors. Some of these racemic mixtures were resolved to their enantiomers and tested for binding to norepinephrine (NE) transporter (NET), dopamine (DA) transporter (DAT), and α2 receptor. Several of these enantiomers [(-)-15b, (-)-15j, (-)-15t, (+)-15u] displayed a dual binding profile with affinities for SERT and NET with K i i = 1.9 and 13.5 nM, respectively), and further pharmacological characterization is in progress for its evaluation as a antidepressant.