6396-07-2

Usage

Uses

Used in Organic Synthesis:
DIIODOTRIPHENYLPHOSPHORANE is used as a reagent for the conversion of alcohol, thiol, and enol functional groups into alkyl iodides via the formation of alkoxyphosphonium iodide. This conversion is crucial in various organic synthesis processes.
Used in the Preparation of β-Iodo-α,β-Unsaturated Ketones:
DIIODOTRIPHENYLPHOSPHORANE is used as a reagent for the preparation of β-iodo-α,β-unsaturated ketones from cyclic β-diketones in the presence of triethyl amine. This reaction is important in the synthesis of various organic compounds.
Used in the Synthesis of Alkyl Nitrates:
DIIODOTRIPHENYLPHOSPHORANE is used as a reagent in the synthesis of alkyl nitrates from alcohols. This process is essential in the production of various organic compounds.
Used in the Beckmann Rearrangement Reaction:
DIIODOTRIPHENYLPHOSPHORANE is used as a reagent in the Beckmann rearrangement reaction to synthesize lactams from cycloalkanone oxime. This reaction is crucial in the production of various organic compounds.
Used in the Preparation of Carboxylic Acid Esters:
DIIODOTRIPHENYLPHOSPHORANE is used as a reagent for the preparation of aromatic and aliphatic carboxylic acid esters in the presence of N,N-dimethylaminopyridine. This process is important in the synthesis of various organic compounds.
Used in the Reduction of Graphene Oxide:
DIIODOTRIPHENYLPHOSPHORANE can be used to reduce graphene oxide for the production of graphene nanosheets under mild and environmentally friendly conditions. This application is significant in the field of nanotechnology and material science.

InChI:InChI=1/C18H15I2P/c19-21(20,16-10-4-1-5-11-16,17-12-6-2-7-13-17)18-14-8-3-9-15-18/h1-15H

Upstream product

• 2588-88-7 pentaphenylphosphorane 
• 603-35-0 triphenylphosphine 
• 16029-98-4 trimethylsilyl iodide 
• 2526-64-9 dichlorotriphenylphosphorane 
• 93374-06-2 tetraethylphosphorodiamidothioic iodide 
• 2065-67-0 tetraphenylphosphonium iodide 
• 1034-39-5 dibromotriphenylphosphorane 
• 54305-75-8 N,N-diethylaminodiiodophosphine 

Downstream Products

• 7225-35-6 Triphenyliodphosphonium 
• 845-64-7 triphenyldifluorophosphorane 
• 7790-33-2 manganese(II) iodide 
• 23661-58-7 MnI₂(P(C₆H₅)3)2 
• 152442-02-9 {(C₆H₅)3PI}⁽¹⁺⁾*{Ni(P(C₆H₅)3)I₃}^(1-)={(C₆H₅)3PI}{Ni(P(C₆H₅)3)I₃} 
• 149831-14-1 [(C₆H₅)3PI][Co(P(C₆H₅)3)I₃], bright green 
• 164072-11-1 Fe(CO)2I(triphenylphosphine)(η(2)-O=CN((i)Pr)2) 
• 181784-19-0 InI₃(P(C₆H₅)3)*InI₃(P(C₆H₅)3)2 
• 603-35-0 triphenylphosphine 
• 791-28-6 Triphenylphosphine oxide 
• 705298-27-7 [Fe(η(2)-OCNiPr2)(CO)2(PPh3)2]BF4 
• 1198298-17-7 CpCr[(2,6-Me₂C₆H₃NCMe)2CH](I) 
• 149831-14-1 {P(C₆H₅)3I}⁽¹⁺⁾*{CoP(C₆H₅)3I₃}^(1-)={P(C₆H₅)3I}{CoP(C₆H₅)3I₃} 
• 14057-04-6 diiodobis(triphenylphosphine)zinc 

Relevant academic research and scientific papers

3-(1H-PYRAZOL-4-YL)PYRIDINE ALLOSTERIC MODULATORS OF M4 MUSCARINIC ACETYLCHOLINE RECEPTOR

Provided are cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor, compositions comprising said compounds, and uses of said compounds in the treatment or prevention of diseases in which M4 muscarinic acetylcholine receptors are involved, especially neurological and psychiatric disorders and diseases.

Halogenation through Deoxygenation of Alcohols and Aldehydes

An efficient reagent system, Ph3P/XCH2CH2X (X = Cl, Br, or I), was very effective for the deoxygenative halogenation (including fluorination) of alcohols (including tertiary alcohols) and aldehydes. The easily available 1,2-dihaloethanes were used as key reagents and halogen sources. The use of (EtO)3P instead of Ph3P could also realize deoxy-halogenation, allowing for a convenient purification process, as the byproduct (EtO)3Pa?O could be removed by aqueous washing. The mild reaction conditions, wide substrate scope, and wide availability of 1,2-dihaloethanes make this protocol attractive for the synthesis of halogenated compounds.

A Novel Way To Radiolabel Human Butyrylcholinesterase for Positron Emission Tomography through Irreversible Transfer of the Radiolabeled Moiety

The enzyme butyrylcholinesterase (BChE) is known to be involved in the detoxification of xenobiotics in blood plasma and is associated with the progress of neurodegenerative disorders, diabetes type 2, obesity, and diseases of the cardiovascular system. In the present study, we developed carbamate-based inhibitors serving as positron emission tomography (PET) radiotracers with18F and11C as radioisotopes to visualize BChE distribution. These inhibitors are radiolabeled at the carbamate site and transfer this moiety onto BChE, which thus results in covalent and permanent radiolabeling of the enzyme. There are no comparable radiotracers for cholinesterases described to date. By ex vivo autoradiography experiments on mice brain slices and kinetic investigations, selective and covalent transfer of the radiolabeled carbamate moiety onto BChE was proven. These tracers might provide high resolution of BChE distribution in vivo to enable investigations into the pathophysiological mechanisms of diseases associated with alterations in BChE occurrence.

SPIRO(5.5)UNDECANE DERIVATIVES

The invention relates to compounds that have an affinity to the μ-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain and other conditions.

Derivatives of triterpenoid acids as inhibitors of cell-adhesion molecules ELAM-1 (E-selectin) and LECAM-1 (L-selectin)

Triterpenoid acid derivatives have been found to have structures similar to natural ligands to the extent that these derivatives bind to natural selectin receptors including endothelial leukocyte adhesion molecule-1 (ELAM-1) and leukocyte/endothelial cell adhesion molecule-1 (LECAM-1). The molecules can be administered to the patients by themselves or in pharmaceutical formulations; in order to alleviate inflammation and/or treat other abnormalities associated with the excessive binding of leukocytes to endothelial receptors.