6396-53-8

Upstream product

• 37908-98-8 methyl 3-chloro-p-anisate 
• 14503-45-8 3-chloro-4-methoxybenzyl alcohol 
• 4903-09-7 3-chloro-4-methoxy-benzaldehyde 
• 1530-32-1 ethyltriphenylphosphonium bromide 

Downstream Products

• 169217-47-4 (+/-)-(1R,2S)-1-(3'-chloro-4'-methoxyphenyl)-1,2-propanediol 
• 169217-47-4 (1S,2R)-1-(3'-chloro-4'-methoxyphenyl)-1,2-propanediol 
• 169217-47-4 (1R,2S)-1-(3'-chloro-4'-methoxyphenyl)-1,2-propanediol 

Relevant academic research and scientific papers

Synthesis of (1R,2S)-1-(3′-chloro-4′-methoxyphenyl)-1,2- propanediol (trametol) and (1R,2S)-1-(3′,5′-dichloro-4′- methoxyphenyl)-1,2-propanediol, chlorinated fungal metabolites in the natural environment

(1R,2S)-1-(3′-Chloro-4′-methoxyphenyl)-1,2-propanediol (Trametol, 3), a metabolite of the fungus Trametes sp. IVP-F640 and Bjerkandera sp. BOS55, was synthesized by employing Sharpless asymmetric dihydroxylation as the key step. Similarly, the (1R,2S)-isomer of 1-(3′,5′-dichloro- 4′-methoxyphenyl)-1,2-propanediol (4), another metabolite of Bjerkandera sp. BOS55, was synthesized by asymmetric dihydroxylation.