169217-47-4

Usage

General Description

1,2-Propanediol,1-(3-chloro-4-methoxyphenyl)-, (1R,2S)- is a chemical compound with the molecular formula C9H11O4Cl. Also known as dexketoprofen, it is an active ingredient in non-steroidal anti-inflammatory drugs (NSAIDs) and is used for its pain-relieving and anti-inflammatory properties. Dexketoprofen is commonly administered as a tablet or injection to treat moderate to severe pain, such as that caused by arthritis, dental procedures, and sports injuries. It works by inhibiting the production of prostaglandins, which are chemicals in the body that cause pain and inflammation. However, like other NSAIDs, dexketoprofen can have side effects, including stomach ulcers, gastrointestinal bleeding, and kidney problems, and it should be used with caution, especially in older adults and those with certain medical conditions.

Upstream product

• 213470-67-8 1-(3-Chloro-4-methoxy-phenyl)-2-hydroxy-propan-1-one 
• 6396-53-8 (Z)-2-chloro-4-(1'-propenyl)anisole 
• 37908-98-8 methyl 3-chloro-p-anisate 
• 14503-45-8 3-chloro-4-methoxybenzyl alcohol 
• 4903-09-7 3-chloro-4-methoxy-benzaldehyde 
• 4394-54-1 1-(3'-chloro-4'-methoxyphenyl)-1-propanone 
• 213470-63-4 (+/-)-1-(3'-chloro-4'-methoxyphenyl)-1-propanol 

Relevant academic research and scientific papers

Synthesis of (1R,2S)-1-(3′-chloro-4′-methoxyphenyl)-1,2- propanediol (trametol) and (1R,2S)-1-(3′,5′-dichloro-4′- methoxyphenyl)-1,2-propanediol, chlorinated fungal metabolites in the natural environment

(1R,2S)-1-(3′-Chloro-4′-methoxyphenyl)-1,2-propanediol (Trametol, 3), a metabolite of the fungus Trametes sp. IVP-F640 and Bjerkandera sp. BOS55, was synthesized by employing Sharpless asymmetric dihydroxylation as the key step. Similarly, the (1R,2S)-isomer of 1-(3′,5′-dichloro- 4′-methoxyphenyl)-1,2-propanediol (4), another metabolite of Bjerkandera sp. BOS55, was synthesized by asymmetric dihydroxylation.

Identification and synthesis of novel chlorinated p-anisylpropanoid metabolites from Bjerkandera species

Analysis of the EtOAc extracts from the culture medium of Bjerkandera sp. BOS55 and B. fumosa revealed the presence of two novel chlorinated metabolites. Their structures were unambiguously established as erythro-1- (3',5'-dichloro-4'-methoxyphenyl)-1,2-propanediol (2) and 1-(3'-chloro-4'- methoxyphenyl)-3-hydroxy-1-propanone (3) through synthesis of authentic samples and comparison of retention times and mass spectral data. The production of trametol (1) by Bjerkandera sp, BOS55 was also a new finding.