6397-99-5Relevant academic research and scientific papers
Ugi four component condensations using aldehydes with an asymmetric centre at C-2
Kelly,Lawrie,Morgan,Willis
, p. 8001 - 8005 (2007/10/03)
Epimerisation of an aldehyde possessing a hydrocarbon substituent α to the carbonyl occurs in the Ugi four component condensation whereas, with either a benzyl or TBDMS ether at C-2 the stereochemical integrity is maintained. A deuterium isotope effect is observed and by carrying out the reaction in methanol-OD, deuterium can be introduced efficiently into C-3 of the condensation products. (C) 2000 Elsevier Science Ltd.
